There has been an explosive growth of interest in the multiple interacting paracrine systems
that influence renal microvascular function. This review first discusses the membrane …

Nitric oxide (NO) is an important molecular mediator of numerous physiological processes in
virtually every organ. In the kidney, NO plays prominent roles in the homeostatic regulation …

Recent studies have indicated that acute inhibition of nitric oxide biosynthesis in the rat
promotes arterial hypertension and renal vasoconstriction. We evaluated the renal and …

Tonic basal release of nitric oxide (NO) by vascular endothelial cells controls blood pressure
(BP) in the basal state. In these studies we investigated the effects of chronic inhibition of …

There are gender-associated differences in blood pressure (BP) in humans, with men
having higher BP than age-matched pre-menopausal women and being at greater risk for …

The discovery in 1987 that endothelium-derived nitric oxide (NO) mediates the vasodilatory
effect of certain endothelium-dependent agonists1, 2 inaugurated the current huge field of …

Nitric oxide is a pluripotential molecule that acts as both an autocrine and paracrine
mediator of homoeostasis, and derangement of its metabolism can be linked with many …

The characterization and cloning of constitutive and inducible nitric oxide (NO)-synthesizing
enzymes and the development of specific inhibitors of the L-arginine NO pathway have …

DESPITE unequivocal evidence that renal function is altered in hypertension, certain
important issues are unresolved. The most controversial area is whether the observed …

The review deals with the release of endothelium-derived dopamine and 6-nitrodopamine (6-
ND) and its effects on isolated vascular tissues and isolated hearts. Basal release of both …