Hepatocellular carcinoma (HCC) is one of the main cancer-related causes of death
worldwide. Thus, there is a constant search for improvement in screening, diagnosis, and …

Patients who develop chronic fibrotic liver disease, caused by viral or metabolic aetiologies,
are at a high risk of developing hepatocellular carcinoma (HCC). Even after complete HCC …

Hepatocyte differentiation, proliferation, and apoptosis are affected by growth factors
produced in liver. Insulin-like growth factor 1 and 2 (IGF1 and IGF2) act in response to …

Background It is well known that the incidence of developing hepatocelluler carcinoma
(HCC) is increased in liver cirrhosis of different etiologies. However, comparison of HCC …

Emerging data indicate that the mortality rate of hepatocellular carcinoma (HCC) associated
with cirrhosis is rising in some developed countries, whereas mortality from non-HCC …

Hepatocellular carcinoma (HCC) is the third leading cause of cancer-related deaths
worldwide. Only 30%-40% of the patients with HCC are eligible for curative treatments …

Hepatocellular carcinoma (HCC) mortality remains high primarily due to late diagnosis as a
consequence of failed early detection. Professional societies recommend semi‐annual HCC …

BACKGROUND & AIMS: IGF signaling has a relevant role in a variety of human
malignancies. We analyzed the underlying molecular mechanisms of IGF signaling …

Determination of the role of insulin-like growth factor (IGF) family components in
carcinogenesis of several human tumors is based on numerous epidemiological and pre …

Strong evidence emphasizes the role of the insulin-like growth factor (IGF) system and of
type-I IGF receptor (IGF-IR) signalling in tumourigenesis. In this connection:(i) changes in the …