Tumor suppressor genes

RA Weinberg - Science, 1991 - science.org
For the past decade, cellular oncogenes have attracted the attention of biologists intent on
understanding the molecular origins of cancer. As the present decade unfolds, oncogenes …

The cell-cell channel in the control of growth

WR Loewenstein, B Rose - Seminars in cell biology, 1992 - Elsevier
Several lines of evidence indicate that the cell-cell channels in gap junction are conduits for
growth-regulating signals. Experimental upregulalion of the channels by retinoids causes …

Connexin43 mediates direct intercellular communication in human osteoblastic cell networks.

R Civitelli, EC Beyer, PM Warlow… - The Journal of …, 1993 - Am Soc Clin Investig
We have examined cell coupling and expression of gap junction proteins in monolayer
cultures of cells derived from human bone marrow stromal cells (BMC) and trabecular bone …

Intercellular communication and carcinogenesis

H Yamasaki, M Mesnil, Y Omori, N Mironov… - Mutation Research …, 1995 - Elsevier
Two types of intercellular communication (humoral and cell contact-mediated) are involved
in control of cellular function in multicellular organisms, both of them mediated by membrane …

Suppression of human prostate cancer cell growth by forced expression of connexin genes

PP Mehta, C Perez‐Stable, M Nadji… - Developmental …, 1999 - Wiley Online Library
The cell‐to‐cell channels in gap junctions, formed of proteins called connexins (Cxs),
provide a direct intercellular pathway for the passage of small signaling molecules (≤ 1 kD) …

The Tumor Promoter 12-O-Tetradecanoylphorbol-13-Acetate and the ras Oncogene Modulate Expression and Phosphorylation of Gap Junction Proteins

JL Brissette, NM Kumar, NB Gilula… - Molecular and cellular …, 1991 - Taylor & Francis
Gap junctional intercellular communication is inhibited in response to tumor promoters and
oncogene transformation, suggesting that loss of this function is an important step in tumor …

Growth retardation in glioma cells cocultured with cells overexpressing a gap junction protein.

D Zhu, GM Kidder, S Caveney… - Proceedings of the …, 1992 - National Acad Sciences
To examine the role of gap-junctional intercellular communication in controlling cell
proliferation, we have transfected C6 glioma cells with connexin 43 cDNA. The growth of …

Endogenous and exogenous modulation of gap junctional intercellular communication: toxicological and pharmacological implications

JE Trosko, BV Madhukar, CC Chang - Life sciences, 1993 - Elsevier
During the evolution of single-celled organisms to multicellular metazoans, a family of highly
conserved genes coding for proteins (connexins), which as hexameric units (connexons) …

Regulation of connexin43 function by activated tyrosine protein kinases

AF Lau, WE Kurata, MY Kanemitsu, LWM Loo… - Journal of bioenergetics …, 1996 - Springer
Gap junctions are specialized membrane structures that are involved in the normal
functioning of numerous mammalian tissues and implicated in several human disease …

The embryonic environment strongly attenuates v-src oncogenesis in mesenchymal and epithelial tissues, but not in endothelia.

AW Stoker, C Hatier, MJ Bissell - The Journal of cell biology, 1990 - rupress.org
We demonstrate that the behavior of cells expressing v-src, a tyrosine kinase oncogene,
differs profoundly between the embryonic and culture environments. V-src was introduced …