As the population ages, the number of operations performed on bone is expected to
increase. Diseases such as arthritis, tumours, and trauma can lead to defects in the skeleton …

The vast majority of total hip prostheses currently implanted consist of a hard metal or
ceramic femoral head articulating against an ultra-high molecular weight polyethylene …

So far, the human health impacts of nano-and microplastics are poorly understood. Thus, we
investigated whether nanoplastics exposure induces inflammatory processes in primary …

Biologic response to orthopedic implants debris is central to clinical performance. Eventual
implant loosening due to aseptic osteolysis has been attributed to local inflammatory …

Particulate wear debris from total hip prosthetic components can stimulate macrophages to
produce mediators of osteolysis which may cause aseptic implant loosening. This study …

Since the recognition of aseptic loosening by Charnley in the early 1960s, much information
has been gained on the basic science of periprosthetic bone loss. Initially termed cement …

Polyethylene wear debris generated at the bearing surfaces of total artificial hip joints is
thought to play an important role in the periprosthetic osteolysis and ultimately the aseptic …

Natural coral graft substitutes are derived from the exoskeleton of marine madreporic corals.
Researchers first started evaluating corals as potential bone graft substitutes in the early …

Background: Loosening of the implant after total joint arthroplasty remains a serious
problem. The activation of macrophages by wear debris from implants, mediated by the …

Conventional materials technology has yielded clear improvements in regenerative
medicine. Ideally, however, a replacement material should mimic the living tissue …