Mitogen-activated protein (MAP) kinases are a central component in signaling networks in a
multitude of mammalian cell types. This review covers recent advances on specific functions …

Neurotransmitter switching is the gain of one neurotransmitter and the loss of another in the
same neuron in response to chronic stimulation. Neurotransmitter receptors on postsynaptic …

Abstract The endosome-associated GTPase Rab5 is a central player in the molecular
mechanisms leading to degeneration of basal forebrain cholinergic neurons (BFCN), a long …

The autonomic nervous system is a master regulator of homeostatic processes and stress
responses. Sympathetic noradrenergic nerve fibers decrease bone mass, but the role of …

There are several candidate signalling pathways that mediate the response of the central
nervous system (CNS) cells to environmental toxins. However, much is still to be learned on …

The main goal of regenerative medicine is to replace damaged tissue. To do this it is
necessary to understand in detail the whole regeneration process including differentiated …

SATB2 is a risk locus for schizophrenia and encodes a DNA-binding protein that regulates
higher-order chromatin configuration. In the adult brain Satb2 is almost exclusively …

Glycoprotein 130 (gp130) is the signal transducing receptor subunit for cytokines of the
interleukin-6 (IL-6) family, and it is expressed in a multitude of cell types of the immune and …

Alzheimer's disease (AD) is a neurodegenerative disorder, characterized by the formation of
amyloid β and tau protein aggregates in the brain, neuroinflammation, impaired cholinergic …

SATB2 is a schizophrenia risk gene and is genetically associated with human intelligence.
How it affects cognition at molecular level is currently unknown. Here, we show that …