The ability to site-selectively modify equivalent functional groups in a molecule has the
potential to streamline syntheses and increase product yields by lowering step counts …

The human microbiome and its metabolic output play an important role in shaping human
health and disease. The host-microbe crosstalk is often characterised using metabolomics …

Single crystal X-ray diffraction is considered to be a highly reliable method for determining
the molecular structures and absolute conformation at the atomic level, but this technique is …

Filamentous fungi are one of the most important producers of secondary metabolites. Some
of them can have a toxic effect on the human body, leading to diseases. On the other hand …

Genomics-guided methodologies have revolutionized the discovery of natural products.
However, a major challenge in the field of genome mining is determining how to selectively …

Microbial secondary metabolites are a rich source for pharmaceutical discoveries and play
crucial ecological functions. While tools exist to identify secondary metabolite clusters in …

Modified cyclic dipeptides represent a widespread class of secondary metabolites with
diverse pharmacological activities, including antibacterial, antifungal, and antitumor. Here …

Natural products have long served as critical raw materials in chemical and pharmaceutical
manufacturing, primarily which can provide superior scaffolds or intermediates for drug …

Pyridoxal 5′-phosphate (PLP)-dependent enzymes are the most versatile biocatalysts for
synthesizing nonproteinogenic amino acids. α, α-Disubstituted quaternary amino acids, such …

Natural products biosynthesized from biocontrol fungi in the rhizosphere can have both
beneficial and deleterious effects on plants. Herein, we performed a comprehensive …