Macrophages are ancient, phagocytic immune cells thought to have their origins 500 million
years ago in metazoan phylogeny. The understanding of macrophages has evolved to …

Hypoxia has been shown to contribute to tumor immunosuppressive microenvironment and
is an effective prognostic indicator. This study aimed to screen prognostic hypoxia-related …

Microglia/macrophages make up the largest population of tumor-infiltrating cells. Numerous
studies have demonstrated that glioma-associated microglia/macrophages (GAMs) could …

Aim: To molecularly characterize the tumor microenvironment and evaluate immunologic
parameters in canine glioma patients before and after treatment with oncolytic human IL-12 …

Under the influence of transforming growth factor-beta (TGFβ), glioma-associated microglia
produce molecules that promote glioma growth and invasion. Olfactomedin-like 3 (Olfml3), a …

Purpose: Activation of STING (s timulator of in terferon g enes) can trigger a robust, innate
antitumor immune response in immunologically “cold” tumors such as glioblastoma. Patients …

The Peritumoral Brain Zone (PBZ) contributes to Glioblastoma (GBM) relapse months after
the resection of the original tumor, which is influenced by a variety of pathological factors …

Simple Summary Gliomas develop in the central nervous system from the glial cells that
support it. Low-grade gliomas (LGGs) are characterized by a reduced number of immune …

Simple Summary Canine oligodendrogliomas are universally fatal primary brain tumors.
Glioma-associated microglia/macrophages (GAMs) have been shown to contribute to …

Purpose Spontaneously occurring glioma in pet dogs is increasingly recognized as a
valuable translational model for human glioblastoma. Canine high-grade glioma and human …