The proliferator-activated receptor γ (PPARγ), a member of the nuclear receptor superfamily,
is one of the most extensively studied ligand-inducible transcription factors. Since its …

The worldwide obesity epidemic has emerged as a major cause of insulin resistance and
Type 2 diabetes. Chronic tissue inflammation is a well-recognized feature of obesity, and the …

ABSTRACT N 6-methyladenosine (m6A), the most abundant internal modification on
mRNAs in eukaryotes, play roles in adipogenesis. However, the underlying mechanism …

Thyroid hormone (TH) is required for normal development as well as regulating metabolism
in the adult. The thyroid hormone receptor (TR) isoforms, α and β, are differentially …

There has been an upsurge of interest in the adipocyte coincident with the onset of the
obesity epidemic and the realization that adipose tissue plays a major role in the regulation …

Cdk5 is a proline-directed serine/threonine protein kinase that governs a variety of cellular
processes in neurons, the dysregulation of which compromises normal brain function. The …

Glucose and fatty acids are the major sources of energy for human body. Cholesterol, the
most abundant sterol in mammals, is a key component of cell membranes although it does …

Adipose tissue hypoxia and inflammation have been causally implicated in obesity-induced
insulin resistance. Here, we report that, early in the course of high-fat diet (HFD) feeding and …

Type 2 diabetes is caused by insulin resistance coupled with an inability to produce enough
insulin to control blood glucose, and thiazolidinediones (TZDs) are the only current …

Nuclear receptors (NRs) are ligand-dependent transcription factors whose activation affects
genes controlling vital processes. Among them, the peroxisome proliferator-activated …