Metabolism at the crossroads of inflammation and fibrosis in chronic kidney disease
Chronic kidney disease (CKD), defined as persistent (> 3 months) kidney functional loss,
has a growing prevalence (> 10% worldwide population) and limited treatment options …
has a growing prevalence (> 10% worldwide population) and limited treatment options …
Integration of spatial and single-cell data across modalities with weakly linked features
Although single-cell and spatial sequencing methods enable simultaneous measurement of
more than one biological modality, no technology can capture all modalities within the same …
more than one biological modality, no technology can capture all modalities within the same …
NAD+ precursor supplementation prevents mtRNA/RIG-I-dependent inflammation during kidney injury
Our understanding of how global changes in cellular metabolism contribute to human kidney
disease remains incompletely understood. Here we show that nicotinamide adenine …
disease remains incompletely understood. Here we show that nicotinamide adenine …
[HTML][HTML] Spatial transcriptomics: Integrating morphology and molecular mechanisms of kidney diseases
P Isnard, BD Humphreys - The American Journal of Pathology, 2024 - Elsevier
The recent arrival of high-resolution spatial transcriptomics (ST) technologies is generating a
veritable revolution in life sciences, enabling biomolecules to be measured in their native …
veritable revolution in life sciences, enabling biomolecules to be measured in their native …
Single-cell transcriptomics and chromatin accessibility profiling elucidate the kidney-protective mechanism of mineralocorticoid receptor antagonists
A Abedini, A Sánchez-Navaro, J Wu… - The Journal of …, 2024 - Am Soc Clin Investig
Mineralocorticoid excess commonly leads to hypertension (HTN) and kidney disease. In our
study, we used single-cell expression and chromatin accessibility tools to characterize the …
study, we used single-cell expression and chromatin accessibility tools to characterize the …
Niche-DE: niche-differential gene expression analysis in spatial transcriptomics data identifies context-dependent cell-cell interactions
Existing methods for analysis of spatial transcriptomic data focus on delineating the global
gene expression variations of cell types across the tissue, rather than local gene expression …
gene expression variations of cell types across the tissue, rather than local gene expression …
Transcriptomic, epigenomic, and spatial metabolomic cell profiling redefines regional human kidney anatomy
A large-scale multimodal atlas that includes major kidney regions is lacking. Here, we
employed simultaneous high-throughput single-cell ATAC/RNA sequencing (SHARE-seq) …
employed simultaneous high-throughput single-cell ATAC/RNA sequencing (SHARE-seq) …
Molecular pathways that drive diabetic kidney disease
Kidney disease is a major driver of mortality among patients with diabetes and diabetic
kidney disease (DKD) is responsible for close to half of all chronic kidney disease cases …
kidney disease (DKD) is responsible for close to half of all chronic kidney disease cases …
Multi-omics analyses identify AKR1A1 as a biomarker for diabetic kidney disease
Diabetic kidney disease (DKD) is the leading cause of end-stage kidney disease. As many
genes associate with DKD, multi-omics approaches were employed to narrow the list of …
genes associate with DKD, multi-omics approaches were employed to narrow the list of …
Spatial transcriptomics in health and disease
S Jain, MT Eadon - Nature Reviews Nephrology, 2024 - nature.com
The ability to localize hundreds of macromolecules to discrete locations, structures and cell
types in a tissue is a powerful approach to understand the cellular and spatial organization …
types in a tissue is a powerful approach to understand the cellular and spatial organization …