Intranasal COVID-19 vaccines: From bench to bed

A Alu, L Chen, H Lei, Y Wei, X Tian, X Wei - EBioMedicine, 2022 - thelancet.com
Currently licensed COVID-19 vaccines are all designed for intramuscular (IM) immunization.
However, vaccination today failed to prevent the virus infection through the upper respiratory …

Nanotechnology's frontier in combatting infectious and inflammatory diseases: prevention and treatment

Y Huang, X Guo, Y Wu, X Chen, L Feng, N Xie… - … and Targeted Therapy, 2024 - nature.com
Inflammation-associated diseases encompass a range of infectious diseases and non-
infectious inflammatory diseases, which continuously pose one of the most serious threats to …

Scientific rationale for developing potent RBD-based vaccines targeting COVID-19

H Kleanthous, JM Silverman, KW Makar, IK Yoon… - npj Vaccines, 2021 - nature.com
Vaccination of the global population against COVID-19 is a great scientific, logistical, and
moral challenge. Despite the rapid development and authorization of several full-length …

Mucosal vaccines, sterilizing immunity, and the future of SARS-CoV-2 virulence

D Focosi, F Maggi, A Casadevall - Viruses, 2022 - mdpi.com
Sterilizing immunity after vaccination is desirable to prevent the spread of infection from
vaccinees, which can be especially dangerous in hospital settings while managing frail …

Functionalizing ferritin nanoparticles for vaccine development

MQ Rodrigues, PM Alves, A Roldão - Pharmaceutics, 2021 - mdpi.com
In the last decade, the interest in ferritin-based vaccines has been increasing due to their
safety and immunogenicity. Candidates against a wide range of pathogens are now on …

Untangling mucosal drug delivery: engineering, designing, and testing nanoparticles to overcome the mucus barrier

J Watchorn, AJ Clasky, G Prakash… - ACS Biomaterials …, 2022 - ACS Publications
Mucus is a complex viscoelastic gel and acts as a barrier covering much of the soft tissue in
the human body. High vascularization and accessibility have motivated drug delivery to …

Molecular aspects concerning the use of the SARS-CoV-2 receptor binding domain as a target for preventive vaccines

Y Valdes-Balbin, D Santana-Mederos… - ACS central …, 2021 - ACS Publications
The development of recombinant COVID-19 vaccines has resulted from scientific progress
made at an unprecedented speed during 2020. The recombinant spike glycoprotein …

Lyophilized, thermostable Spike or RBD immunogenic liposomes induce protective immunity against SARS-CoV-2 in mice

MT Mabrouk, K Chiem, E Rujas, WC Huang… - Science …, 2021 - science.org
The COVID-19 pandemic has spurred interest in potent and thermostable SARS-CoV-2
vaccines. Here, we assess low-dose immunization with lyophilized nanoparticles decorated …

Advanced materials for SARS‐CoV‐2 vaccines

MT Mabrouk, WC Huang… - Advanced …, 2022 - Wiley Online Library
The ongoing coronavirus disease 2019 (COVID‐19) pandemic, caused by severe acute
respiratory coronavirus 2 (SARS‐CoV‐2), has killed untold millions worldwide and has …

A ferritin nanoparticle-based zika virus vaccine candidate induces robust humoral and cellular immune responses and protects mice from lethal virus challenge

A Pattnaik, BR Sahoo, LR Struble, GEO Borgstahl… - Vaccines, 2023 - mdpi.com
The severe consequences of the Zika virus (ZIKV) infections resulting in congenital Zika
syndrome in infants and the autoimmune Guillain–Barre syndrome in adults warrant the …