Phthalates are one of the most widely used plasticizers in polymer products, and they are
increasingly being exposed to people all over the world, generating health concerns …

In-vitro dissolution testing of pharmaceutical formulations has been used as a quality control
test for many years. At early drug product development, in vivo predictive dissolution testing …

The interplay between drug and polymer chemistry and its impact on drug release from an
amorphous solid dispersion (ASD) is a relatively underexplored area. Herein, the release …

The rate and extent of drug dissolution in the gastrointestinal (GI) tract are highly dependent
upon drug physicochemical properties and GI fluid properties. Biorelevant dissolution media …

Inflammatory bowel disease (IBD) is a debilitating condition, estimated to affect 7 million
people worldwide. Current IBD treatment strategies are substandard, relying on colonic …

Orally dosed drugs must dissolve in the gastrointestinal (GI) tract before being absorbed
through the epithelial cell membrane. In vivo drug dissolution depends on the GI tract's …

Dissolution is a crucial process for the oral delivery of drug products. Before being absorbed
through epithelial cell membranes to reach the systemic circulation, drugs must first dissolve …

Several locally acting colon-targeted products to treat colonic diseases have been recently
developed and marketed, taking advantage of gastrointestinal physiology to target delivery …

The main buffering system influencing ionizable drug dissolution in the human intestinal
fluid is bicarbonate-based; however, it is rarely used in routine pharmaceutical practice due …

The purpose of this study was to develop a bicarbonate buffer flow-through cell (FTC)
dissolution test. Mesalazine colon targeting tablets of a generic development product (test …