Progressing nanotechnology to improve targeted cancer treatment: overcoming hurdles in its clinical implementation

M Chehelgerdi, M Chehelgerdi, OQB Allela… - Molecular cancer, 2023 - Springer
The use of nanotechnology has the potential to revolutionize the detection and treatment of
cancer. Developments in protein engineering and materials science have led to the …

Where is nano today and where is it headed? A review of nanomedicine and the dilemma of nanotoxicology

C Domingues, A Santos, C Alvarez-Lorenzo… - ACS …, 2022 - ACS Publications
Worldwide nanotechnology development and application have fueled many scientific
advances, but technophilic expectations and technophobic demands must be …

Passage of exogeneous fine particles from the lung into the brain in humans and animals

Y Qi, S Wei, T Xin, C Huang, Y Pu… - Proceedings of the …, 2022 - National Acad Sciences
There are still significant knowledge gaps in understanding the intrusion and retention of
exogeneous particles into the central nervous system (CNS). Here, we uncovered various …

Understanding nanomaterial–liver interactions to facilitate the development of safer nanoapplications

J Li, C Chen, T Xia - Advanced Materials, 2022 - Wiley Online Library
Nanomaterials (NMs) are widely used in commercial and medical products, such as
cosmetics, vaccines, and drug carriers. Exposure to NMs via various routes such as dermal …

Converting nanotoxicity data to information using artificial intelligence and simulation

X Yan, T Yue, DA Winkler, Y Yin, H Zhu… - Chemical …, 2023 - ACS Publications
Decades of nanotoxicology research have generated extensive and diverse data sets.
However, data is not equal to information. The question is how to extract critical information …

[HTML][HTML] Challenges and opportunities to penetrate the blood-brain barrier for brain cancer therapy

DH Upton, C Ung, SM George, M Tsoli, M Kavallaris… - Theranostics, 2022 - ncbi.nlm.nih.gov
Despite significant advances in research, the prognosis for both primary and secondary
brain cancers remains poor. The blood-brain barrier (BBB) is a complex and unique semi …

Penetration and translocation of functional inorganic nanomaterials into biological barriers

Y Cong, D Baimanov, Y Zhou, C Chen… - Advanced Drug Delivery …, 2022 - Elsevier
With excellent physicochemical properties, inorganic nanomaterials (INMs) have exhibited a
series of attractive applications in biomedical fields. Biological barriers prevent successful …

Nickel oxide nanoparticles improve soybean yield and enhance nitrogen assimilation

P Zhou, Y Jiang, M Adeel, N Shakoor… - Environmental …, 2023 - ACS Publications
Nickel (Ni) is a trace element beneficial for plant growth and development and could
improve crop yield by stimulating urea decomposition and nitrogen-fixing enzyme activity. A …

In situ label-free X-ray imaging for visualizing the localization of nanomedicines and subcellular architecture in intact single cells

M Cao, Y Wang, L Wang, K Zhang, Y Guan, Y Guo… - Nature …, 2024 - nature.com
Understanding the intracellular behaviors of nanomedicines and morphology variation of
subcellular architecture impacted by nanomaterial–biology (nano–bio) interactions could …

Advanced genetic therapies for the treatment of Rett syndrome: state of the art and future perspectives

M Palmieri, D Pozzer, N Landsberger - Frontiers in Neuroscience, 2023 - frontiersin.org
Loss and gain of functions mutations in the X-linked MECP2 (methyl-CpG-binding protein 2)
gene are responsible for a set of generally severe neurological disorders that can affect both …