Modulating cardiac physiology in engineered heart tissue with the bidirectional optogenetic tool BiPOLES

B Schwarzová, T Stüdemann, M Sönmez… - … -European Journal of …, 2023 - Springer
Optogenetic actuators are rapidly advancing tools used to control physiology in excitable
cells, such as neurons and cardiomyocytes. In neuroscience, these tools have been used to …

Optogenetics meets physiology

S Ohnemus, J Vierock, F Schneider-Warme - Pflügers Archiv-European …, 2023 - Springer
According to its classic definition, optogenetics is a method combining genetic and optical
technologies to observe and/or manipulate cell-type-specific behaviour in intact biological …

Channelrhodopsins for cell-type specific illumination of cardiac electrophysiology

MC Fernández, RA Kopton, A Simon-Chica… - … : Methods and Protocols, 2021 - Springer
Optogenetic approaches have evolved as potent means to investigate cardiac
electrophysiology, with research ranging from the study of arrhythmia mechanisms to effects …

Observing and manipulating cell-specific cardiac function with light

CM Zgierski-Johnston, F Schneider-Warme - Optogenetics: Light-Sensing …, 2021 - Springer
The heart is a complex multicellular organ comprising both cardiomyocytes (CM), which
make up the majority of the cardiac volume, and non-myocytes (NM), which represent the …

Active contribution of transplanted induced pluripotent stem cell-derived cardiomyocytes to left ventricular function in a guinea pig model

TN Stüdemann - 2021 - ediss.sub.uni-hamburg.de
Induced pluripotent stem cell (iPSC)-derived cardiomyocyte transplantation has evolved into
a potential novel therapeutic option for heart failure patients in the past twenty years. It has …