Three-dimensional hydrogel-based organ-like cultures can be applied to study
development, regeneration, and disease in vitro. However, the control of engineered …

Cardiovascular disease is the leading cause of death worldwide and is associated with
approximately 17.9 million deaths each year. Musculoskeletal conditions affect more than …

Intrahepatic islet transplantation is the standard cell therapy for β cell replacement. However,
the shortage of organ donors and an unsatisfactory engraftment limit its application to a …

Skeletal muscle is a functional tissue that accounts for approximately 40% of the human
body mass. It has remarkable regenerative potential, however, trauma and volumetric …

The production of skeletal muscle constructs useful for replacing large defects in vivo, such
as in congenital diaphragmatic hernia (CDH), is still considered a challenge. The standard …

Sarcopenia is an age-related muscle atrophy that has recently been considered a significant
factor in deteriorating the quality of life in elderly individuals. However, currently, there are …

Background Tissue engineered bioscaffolds based on decellularized composites have
gained increasing interest for treatment of various diaphragmatic impairments, including …

Vascularized composite allotransplantation is becoming the emerging standard for
reconstructive surgery treatment for patients with limb trauma and facial injuries involving …

Conjunctival reconstruction is an essential part of ocular surface restoration, especially in
severe conjunctival disorders. Decellularized conjunctival tissues have been used in tissue …

Cellular elements of maturing brain are vulnerable to insults, which lead to
neurodevelopmental defects. There are no established treatments at present. Here we …