Synucleinopathies are a group of neurodegenerative diseases with common pathological
lesions associated with the excessive accumulation and abnormal intracellular deposition of …

Dementia with Lewy bodies and Parkinson's disease dementia are common
neurodegenerative diseases that share similar neuropathological profiles and spectra of …

Parkinson´ s disease (PD) is a progressive neurodegenerative disorder characterized by
both motor and non-motor symptoms. Aggravation of symptoms is mirrored by accumulation …

Understanding the contribution of immune mechanisms to Parkinson's disease
pathogenesis is an important challenge, potentially of major therapeutic implications. To …

Epigenetic clocks are age predictors that use machine-learning models trained on DNA CpG
methylation values to predict chronological or biological age. Increases in predicted …

Multiple system atrophy (MSA) is a rare neurodegenerative disease characterized by
neuronal loss and gliosis, with oligodendroglial cytoplasmic inclusions (GCIs) containing α …

The epigenome—the chemical modifications and chromatin-related packaging of the
genome—enables the same genetic template to be activated or repressed in different …

Parkinson's disease is a highly heterogeneous disorder, encompassing a complex spectrum
of clinical presentation including motor, sleep, cognitive and neuropsychiatric symptoms. We …

A genetic predisposition to central nervous system (CNS) toxicity induced by antimicrobial
drugs (antibiotics, antivirals, antifungals, and antiparasitic drugs) has been suspected …

Dementia with Lewy bodies (DLB) is a common form of dementia with known genetic and
environmental interactions. However, the underlying epigenetic mechanisms which reflect …