Abstract Traditional Chinese Medicine (TCM) has some advantages, such as a multi-
component, multi-target, and overall action, which makes the research on the compatibility of …

Background Maternal oocyte aging is strongly contributing to age-related decline in female
fertility. Coenzyme Q10 (CoQ10) exerts positive effects in improving aging-related …

Background Diminished ovarian reserve (DOR) significantly increases the risk of female
infertility and contributes to reproductive technology failure. Recently, the role of melatonin in …

Bone loss induced by microgravity exposure seriously endangers the astronauts' health, but
its countermeasures still have certain limitations. The study aims to find potential protective …

Hydroxychloroquine (HCQ) is derivative of the heterocyclic aromatic compound quinoline,
which has been used for the treatment of autoimmune diseases. The central purpose of this …

Objective Hydroxychloroquine (HCQ), characterized by a broad effect on immune regulation,
has been widely used in the treatment of autoimmune glomerulonephritis such as lupus …

Objective This study was performed to investigate the multi-targets mechanism of
hydroxychloroquine (HCQ) in the treatment of rheumatoid arthritis (RA). Methods The …

Network pharmacology is an emerging discipline that designs drugs based on systems
biology theory and biological system network analysis. Here, we applied network …

Background Systemic lupus erythematosus is an immunologically dysregulated disease
characterized by the presence of multiple autoantibodies. In SLE, B lymphocytes contribute …

Depression induced by weightlessness exposure in spaceflight has seriously affected
astronauts' psychology and flight missions, but the preventive and treatment methods remain …