Levan nanoparticles with intrinsic CD44-targeting ability for tumor-targeted drug delivery

JS Lee, E Park, H Oh, WI Choi, H Koo - International Journal of Biological …, 2023 - Elsevier
Existing anticancer therapeutics exhibit short half-lives, non-specificity, and severe side
effects. To address this, active-targeting nanoparticles have been developed; however, the …

Blockade of Activin Receptor IIB Protects Arthritis Pathogenesis by Non‐Amplification of Activin A‐ACVR2B‐NOX4 Axis Pathway

J Jeon, H Lee, MS Jeon, SJ Kim, C Choi… - Advanced …, 2023 - Wiley Online Library
Although activin receptor IIB (ACVR2B) is emerging as a novel pathogenic receptor, its
ligand and assembled components (or assembly) are totally unknown in the context of …

Mechanisms of vascular invasion after cartilage injury and potential engineering cartilage treatment strategies

Z Zhao, X Sun, P Tu, Y Ma, Y Guo, Y Zhang… - The FASEB …, 2024 - Wiley Online Library
Articular cartilage injury is one of the most common diseases in orthopedic clinics. Following
an articular cartilage injury, an inability to resist vascular invasion can result in cartilage …

Vat-Based 3D-Bioprinted Scaffolds from Photocurable Bacterial Levan for Osteogenesis and Immunomodulation

YO Waidi, VS Wagh, S Mishra… - …, 2025 - ACS Publications
Emerging techniques of additive manufacturing, such as vat-based three-dimensional (3D)
bioprinting, offer novel routes to prepare personalized scaffolds of complex geometries …

[HTML][HTML] An intra articular injectable Mitocelle recovers dysfunctional mitochondria in cellular organelle disorders

MJ Lim, H Oh, J Jeon, C Cho, JS Lee, Y Hwang… - Bioactive Materials, 2025 - Elsevier
Mitochondrial dysfunction increases ROS production and is closely related to many
degenerative cellular organelle diseases. The NOX4-p22phox axis is a major contributor to …

Au3+-Functionalized Metal–Organic Framework Coordinated Nanotherapeutics for Substrate Self-Supplied Parallel Catalytic and Calcium-Overload-Mediated …

H Zhang, Z Wei, Y Wang, Z Bi, W Han… - ACS Applied Bio …, 2025 - ACS Publications
The multiple enzymatic properties of the Au3+-modified metal–organic framework (Au3+-
MOFs) have made it a functional catalytic system for antitumor treatment. However, in the …

BRD2‐specific inhibitor, BBC0403, inhibits the progression of osteoarthritis pathogenesis in osteoarthritis‐induced C57BL/6 male mice

H Lee, J Nam, H Jang, YS Park, MH Son… - British journal of …, 2024 - Wiley Online Library
Background and Purpose The discovery of new bromo‐and extra‐terminal inhibitors
presents new drugs to treat osteoarthritis (OA). Experimental Approach The new drug …

WGA-M001, a Mixture of Total Extracts of Tagetes erecta and Ocimum basilicum, Synergistically Alleviates Cartilage Destruction by Inhibiting ERK and NF-κB …

E Oh, H Jang, S Ok, J Eom, H Lee, SH Kim… - International Journal of …, 2023 - mdpi.com
Tagetes erecta and Ocimum basilicum are medicinal plants that exhibit anti-inflammatory
effects against various diseases. However, their individual and combined effects on …

Pluronic-coated hydroxypropyl-β-cyclodextrin nanoparticle potentiated chemotherapy on multidrug resistance cancer cells via improved docetaxel loading and P …

JS Lee, H Jeon, H Oh, P Son, D Lee, SY Cheon… - Journal of Drug Delivery …, 2024 - Elsevier
In the pharmaceutical formulation of anticancer drugs, US FDA-approved cyclodextrin (CD)
and its derivates have been widely employed. Among them, hydroxypropyl β-cyclodextrin …