Traumatic brain injury (TBI) remains a significant source of death and permanent disability,
contributing to nearly one-third of all injury related deaths in the United States and exacting …

Living cells can sense mechanical forces and convert them into biological responses.
Similarly, biological and biochemical signals are known to influence the abilities of cells to …

Mechanical forces play important roles in the regulation of various biological processes at
the molecular and cellular level, such as gene expression, adhesion, migration, and cell …

Traumatic brain injury (TBI) occurs when local mechanical load exceeds certain tolerance
levels for brain tissue. Extensive research has been done previously for brain matter …

Mechanical characterization of brain tissue at high loading velocities is crucial for modeling
Traumatic Brain Injury (TBI). During severe impact conditions, brain tissue experiences …

Abstract In the United States over 1.7 million cases of traumatic brain injury are reported
yearly, but predictive correlation of cellular injury to impact tissue strain is still lacking …

In vitro models of traumatic brain injury (TBI) are helping elucidate the pathobiological
mechanisms responsible for dysfunction and delayed cell death after mechanical stimulation …

During severe impact conditions, brain tissue experiences a rapid and complex deformation,
which can be seen as a mixture of compression, tension and shear. Diffuse axonal injury …

The unique viscoelastic nature of axons is thought to underlie selective vulnerability to
damage during traumatic brain injury. In particular, dynamic loading of axons has been …

The mechanical behavior of biological materials has been studied extensively at the tissue,
organ and systems levels. Emerging experimental tools, however, enable quantitative …