The burden of cardiovascular and metabolic diseases worldwide is staggering. The
emergence of systems approaches in biology promises new therapies, faster and cheaper …

Zebrafish (Danio rerio) are rapidly emerging as a useful animal model in neurobehavioral
research. Mounting evidence shows the suitability of zebrafish to model various aspects of …

Cerebrovascular disease is the third most common cause of death in developed countries,
but our understanding of the cells that compose the cerebral vasculature is limited. Here …

The mesencephalic locomotor region (MLR) is a brain stem area whose stimulation triggers
graded forward locomotion. How MLR neurons recruit downstream vsx2+(V2a) …

Understanding brain-wide neuronal dynamics requires a detailed map of the underlying
circuit architecture. We built an interactive cellular-resolution atlas of the zebrafish brain at 6 …

Endothelial cells (ECs) line the inside of blood vessels and respond to mechanical cues
generated by blood flow. Mechanical stimuli regulate the localization of YAP by reorganizing …

The type II bacterial CRISPR/Cas9 system is rapidly becoming popular for genome-
engineering due to its simplicity, flexibility and high efficiency. Recently, targeted knock-in of …

A long-standing goal of biology is to map the behavior of all cells during vertebrate
embryogenesis. We developed digital scanned laser light sheet fluorescence microscopy …

The myelination of axons by oligodendrocytes markedly affects CNS function, but how this is
regulated by neuronal activity in vivo is not known. We found that blocking synaptic vesicle …

Developing cardiovascular systems use mechanical forces to take shape, but how
ubiquitous blood flow forces instruct local cardiac cell identity is still unclear. By …