Autophagy is an evolutionarily conserved catabolic cellular process that exerts antiviral
functions during a viral invasion. However, co-evolution and co-adaptation between viruses …

Members of the Flaviviridae virus family comprise a large group of enveloped viruses with a
single-strand RNA genome of positive polarity. Several genera belong to this family …

Dengue virus (DENV) is a mosquito-borne Flavivirus that is endemic in many tropical and
sub-tropical countries where the transmission vectors Aedes spp. mosquitoes resides. There …

The ATG8 family proteins are critical players in autophagy, a cytoprotective process that
mediates degradation of cytosolic cargo. During autophagy, ATG8s conjugate to …

Ubiquitylation is one of the most versatile protein post-translational modifications and is
frequently altered during virus infections. Here we employed a functional proteomics screen …

The Flavivirus genus consists of> 70 members including several that are considered
significant human pathogens. Flaviviruses display a broad spectrum of diseases that can be …

Viruses share many attributes in common with extracellular vesicles (EVs). The cellular
machinery that is used for EV production, packaging of substrates and secretion is also …

Autophagy classically functions to maintain cell health during stressful conditions by
targeting cytosolic components for degradation and recycling via lysosomal pathways …

Hijacking and manipulation of host cell biosynthetic pathways by human enveloped viruses
are essential for the viral lifecycle. Flaviviridae members, including hepatitis C, dengue and …

Lipid droplets (LD) have long been considered as mere fat drops; however, LD have lately
been revealed to be ubiquitous, dynamic and to be present in diverse organelles in which …