Structural determinants and mechanism of HIV-1 genome packaging
K Lu, X Heng, MF Summers - Journal of molecular biology, 2011 - Elsevier
Like all retroviruses, the human immunodeficiency virus selectively packages two copies of
its unspliced RNA genome, both of which are utilized for strand-transfer-mediated …
its unspliced RNA genome, both of which are utilized for strand-transfer-mediated …
The remarkable frequency of human immunodeficiency virus type 1 genetic recombination
A Onafuwa-Nuga, A Telesnitsky - Microbiology and Molecular …, 2009 - Am Soc Microbiol
The genetic diversity of human immunodeficiency virus type 1 (HIV-1) results from a
combination of point mutations and genetic recombination, and rates of both processes are …
combination of point mutations and genetic recombination, and rates of both processes are …
Retroviral RNA dimerization: from structure to functions
N Dubois, R Marquet, JC Paillart… - Frontiers in …, 2018 - frontiersin.org
The genome of the retroviruses is a dimer composed by two homologous copies of genomic
RNA (gRNA) molecules of positive polarity. The dimerization process allows two gRNA …
RNA (gRNA) molecules of positive polarity. The dimerization process allows two gRNA …
[HTML][HTML] Understanding retroviral life cycle and its genomic RNA packaging
Members of the family Retroviridae are important animal and human pathogens. Being
obligate parasites, their replication involves a series of steps during which the virus hijacks …
obligate parasites, their replication involves a series of steps during which the virus hijacks …
Probing the HIV-1 genomic RNA trafficking pathway and dimerization by genetic recombination and single virion analyses
Once transcribed, the nascent full-length RNA of HIV-1 must travel to the appropriate host
cell sites to be translated or to find a partner RNA for copackaging to form newly generated …
cell sites to be translated or to find a partner RNA for copackaging to form newly generated …
Mechanisms and factors that influence high frequency retroviral recombination
With constantly changing environmental selection pressures, retroviruses rely upon
recombination to reassort polymorphisms in their genomes and increase genetic diversity …
recombination to reassort polymorphisms in their genomes and increase genetic diversity …
Retroviral RNA dimerization and packaging: the what, how, when, where, and why
SF Johnson, A Telesnitsky - PLoS pathogens, 2010 - journals.plos.org
Retroviral genomic RNAs (gRNAs) are packaged as dimers, joined near their 5! ends in non-
covalent linkages that withstand modest heat treatment but dissociate at, 65uC …
covalent linkages that withstand modest heat treatment but dissociate at, 65uC …
HIV-1 RNA genome packaging: it's G-rated
A Duchon, WS Hu - Mbio, 2024 - Am Soc Microbiol
ABSTRACT A member of the Retroviridae, human immunodeficiency virus type 1 (HIV-1),
uses the RNA genome packaged into nascent virions to transfer genetic information to its …
uses the RNA genome packaged into nascent virions to transfer genetic information to its …
Recombination is required for efficient HIV-1 replication and the maintenance of viral genome integrity
JMO Rawson, OA Nikolaitchik, BF Keele… - Nucleic acids …, 2018 - academic.oup.com
Retroviruses package two complete RNA genomes into a viral particle but generate only
one provirus after each infection. This pseudodiploid replication strategy facilitates frequent …
one provirus after each infection. This pseudodiploid replication strategy facilitates frequent …
HIV‐1 RNA Packaging
AML Lever - Advances in pharmacology, 2007 - Elsevier
Publisher Summary This chapter focuses on the concept of human immunodeficiency virus
type 1 (HIV‐1) RNA packaging. RNA encapsidation by retroviruses is a remarkable process …
type 1 (HIV‐1) RNA packaging. RNA encapsidation by retroviruses is a remarkable process …