Replacement of the furanosyl oxygen with a methylene unit in the ribose sugar in
nucleosides 1 and nucleotides 2 prompted the rise of a new nucleoside class with very …

Nucleoside analogues are at the forefront of antiviral therapy for last decades. To circumvent
some of their limitations, based on their metabolism, and in order to improve their anti‐viral …

A new class of carbocyclic nucleoside analogues built on a bicyclo [4.1. 0] heptane scaffold,
a perspective novel pseudosugar pattern, have been conceived as anti-HSV agents on the …

The coupling of a nucleobase is a key step in the synthesis of most nucleoside analogs, eg
carbocyclic nucleosides, isonucleosides and acyclic nucleosides. The synthetic strategies …

摘要碳环核苷是呋喃糖环部分被碳环基团取代的核苷类似物. 作为天然核苷的类似物,
许多碳环核苷具有良好的抗病毒, 抗肿瘤活性. 同时, 由于不存在典型的糖苷键 …

O nitrato de amônio cérico (CAN) apresenta uma ampla aplicabilidade em reações
orgânicas, principalmente devido a sua baixa toxicidade, baixo custo, fácil manuseio e bom …

Ceric Ammonium Nitrate (CAN) has a wide applicability in organic reactions, mainly due to
its low toxicity, low cost, easy for handling and good performance in the oxidation reactions …

Carbocyclic nucleosides are nucleoside analogues whose furanose rings are substituted by
carbocycles. As analogues, many carbocyclic nucleosides show good antiviral or antitumor …

Byla vyvinuta metodika přípravy tří typů konformačně uzamčených karbocyklických
nukleodisů založených na" bridgehead" substituovaném norbornanovém skeletu-analoga …