Strategies to access biosynthetic novelty in bacterial genomes for drug discovery
F Hemmerling, J Piel - Nature Reviews Drug Discovery, 2022 - nature.com
Bacteria provide a rich source of natural products with potential therapeutic applications,
such as novel antibiotic classes or anticancer drugs. Bioactivity-guided screening of …
such as novel antibiotic classes or anticancer drugs. Bioactivity-guided screening of …
Linking microbial communities to ecosystem functions: what we can learn from genotype–phenotype mapping in organisms
Microbial physiological processes are intimately involved in nutrient cycling. However, it
remains unclear to what extent microbial diversity or community composition is important for …
remains unclear to what extent microbial diversity or community composition is important for …
Why prokaryotes have pangenomes
JO McInerney, A McNally, MJ O'connell - Nature microbiology, 2017 - nature.com
The existence of large amounts of within-species genome content variability is puzzling.
Population genetics tells us that fitness effects of new variants—either deleterious, neutral or …
Population genetics tells us that fitness effects of new variants—either deleterious, neutral or …
Programmable repression and activation of bacterial gene expression using an engineered CRISPR-Cas system
The ability to artificially control transcription is essential both to the study of gene function
and to the construction of synthetic gene networks with desired properties. Cas9 is an RNA …
and to the construction of synthetic gene networks with desired properties. Cas9 is an RNA …
Community genomic analyses constrain the distribution of metabolic traits across the Chloroflexi phylum and indicate roles in sediment carbon cycling
Background Sediments are massive reservoirs of carbon compounds and host a large
fraction of microbial life. Microorganisms within terrestrial aquifer sediments control buried …
fraction of microbial life. Microorganisms within terrestrial aquifer sediments control buried …
1,003 reference genomes of bacterial and archaeal isolates expand coverage of the tree of life
We present 1,003 reference genomes that were sequenced as part of the Genomic
Encyclopedia of Bacteria and Archaea (GEBA) initiative, selected to maximize sequence …
Encyclopedia of Bacteria and Archaea (GEBA) initiative, selected to maximize sequence …
[HTML][HTML] Horizontal gene transfer from diverse bacteria to an insect genome enables a tripartite nested mealybug symbiosis
The smallest reported bacterial genome belongs to Tremblaya princeps, a symbiont of
Planococcus citri mealybugs (PCIT). Tremblaya PCIT not only has a 139 kb genome, but …
Planococcus citri mealybugs (PCIT). Tremblaya PCIT not only has a 139 kb genome, but …
Analysis of microbial communities in heavy metals-contaminated soils using the metagenomic approach
Soil pollution occurring at mining sites has adverse impacts on soil microbial diversity. New
approaches, such as metagenomics approach, have become a powerful tool to investigate …
approaches, such as metagenomics approach, have become a powerful tool to investigate …
SAR202 genomes from the dark ocean predict pathways for the oxidation of recalcitrant dissolved organic matter
Deep-ocean regions beyond the reach of sunlight contain an estimated 615 Pg of dissolved
organic matter (DOM), much of which persists for thousands of years. It is thought that …
organic matter (DOM), much of which persists for thousands of years. It is thought that …
Evolution of phototrophy in the Chloroflexi phylum driven by horizontal gene transfer
The evolutionary mechanisms behind the extant distribution of photosynthesis is a point of
substantial contention. Hypotheses range from the presence of phototrophy in the last …
substantial contention. Hypotheses range from the presence of phototrophy in the last …