Long-lived species Homo sapiens have evolved robust protection mechanisms against
cancer by repressing telomerase and maintaining short telomeres, thereby delaying the …

In mammals, maintenance of the linear chromosome ends (or telomeres) involves faithful
replication of genetic materials and protection against DNA damage signals, to ensure …

The accumulated evidence has pointed to a key role of telomerase in carcinogenesis. As a
RNA-dependent DNA polymerase, telomerase synthesizes telomeric DNA at the end of …

Aging is a complex process that is not well understood but involves finite changes at the
genetic and epigenetic level. Physical activity is a well-documented modulator of the …

Pulmonary senescence is accelerated by unresolved DNA damage response, underpinning
susceptibility to pulmonary fibrosis. Recently it was reported that the SARS-Cov-2 viral …

Oxidative stress regulates telomere homeostasis and cellular aging by unclear mechanisms.
Glyceraldehyde 3-phosphate dehydrogenase (GAPDH) is a key mediator of many oxidative …

Background Colorectal cancer develops in a multi-step manner from normal epithelium,
through a pre-malignant lesion (so-called adenoma), into a malignant lesion (carcinoma) …

Telomerase expression and telomere maintenance are critical for long-term cell proliferation
and survival, and they play important roles in development, aging, and cancer. Cumulating …

Telomerase is a common hallmark of cancer. Recent studies have shown promising
developments in anti-telomerase cancer immunotherapy, using human telomerase reverse …

The process of aging is mitigated by the maintenance and repair of chromosome ends
(telomeres), resulting in extended lifespan. This review examines the molecular …