The WNT–β-catenin system is an evolutionary conserved signalling pathway that is of
particular importance for morphogenesis and cell organization during embryogenesis. The …

Osteocytes, former osteoblasts encapsulated by mineralized bone matrix, are far from being
passive and metabolically inactive bone cells. Instead, osteocytes are multifunctional and …

The Wnt-β-catenin signaling pathway is an evolutionarily conserved cell-cell communication
system that is important for stem cell renewal, cell proliferation and cell differentiation both …

Wnts are secreted, lipid-modified proteins that bind to different receptors on the cell surface
to activate canonical or non-canonical Wnt signaling pathways, which control various …

Wnt, a secreted glycoprotein, has an approximate molecular weight of 40 kDa, and it is a
cytokine involved in various biological phenomena including ontogeny, morphogenesis …

After discovering that lack of Sost/sclerostin expression is the cause of the high bone mass
human syndromes Van Buchem disease and sclerosteosis, extensive animal …

Denosumab is a potent antiresorptive agent that substantially increases bone mineral
density and reduces fracture rates at all skeletal sites for as long as it is administered …

Receptor activator of NF-κB (RANK) ligand (RANKL) induces the differentiation of monocyte/
macrophage–lineage cells into the bone–resorbing cells called osteoclasts. Because …

The Wnt signaling pathway is known as one of the important molecular cascades that
regulate cell fate throughout lifespan. The Wnt signaling pathway is further separated into …

With ageing, bone tissue undergoes significant compositional, architectural and metabolic
alterations potentially leading to osteoporosis. Osteoporosis is the most prevalent bone …