Antimicrobial susceptibility testing, drug resistance mechanisms, and therapy of infections with nontuberculous mycobacteria
BA Brown-Elliott, KA Nash… - Clinical microbiology …, 2012 - Am Soc Microbiol
Within the past 10 years, treatment and diagnostic guidelines for nontuberculous
mycobacteria have been recommended by the American Thoracic Society (ATS) and the …
mycobacteria have been recommended by the American Thoracic Society (ATS) and the …
Exploiting bacterial DNA gyrase as a drug target: current state and perspectives
F Collin, S Karkare, A Maxwell - Applied microbiology and biotechnology, 2011 - Springer
DNA gyrase is a type II topoisomerase that can introduce negative supercoils into DNA at
the expense of ATP hydrolysis. It is essential in all bacteria but absent from higher …
the expense of ATP hydrolysis. It is essential in all bacteria but absent from higher …
A fast and agnostic method for bacterial genome-wide association studies: Bridging the gap between k-mers and genetic events
Genome-wide association study (GWAS) methods applied to bacterial genomes have
shown promising results for genetic marker discovery or detailed assessment of marker …
shown promising results for genetic marker discovery or detailed assessment of marker …
Molecular mechanisms of antibiotic resistance
GD Wright - Chemical communications, 2011 - pubs.rsc.org
Over the past decade, resistance to antibiotics has emerged as a crisis of global proportion.
Microbes resistant to many and even all clinically approved antibiotics are increasingly …
Microbes resistant to many and even all clinically approved antibiotics are increasingly …
Crystal structure and stability of gyrase–fluoroquinolone cleaved complexes from Mycobacterium tuberculosis
TR Blower, BH Williamson… - Proceedings of the …, 2016 - National Acad Sciences
Mycobacterium tuberculosis (Mtb) infects one-third of the world's population and in 2013
accounted for 1.5 million deaths. Fluoroquinolone antibacterials, which target DNA gyrase …
accounted for 1.5 million deaths. Fluoroquinolone antibacterials, which target DNA gyrase …
A systematic review of gyrase mutations associated with fluoroquinolone-resistant Mycobacterium tuberculosis and a proposed gyrase numbering system
F Maruri, TR Sterling, AW Kaiga… - Journal of …, 2012 - academic.oup.com
Fluoroquinolone resistance in Mycobacterium tuberculosis has become increasingly
important. A review of mutations in DNA gyrase, the fluoroquinolone target, is needed to …
important. A review of mutations in DNA gyrase, the fluoroquinolone target, is needed to …
New Insights into Fluoroquinolone Resistance in Mycobacterium tuberculosis: Functional Genetic Analysis of gyrA and gyrB Mutations
S Malik, M Willby, D Sikes, OV Tsodikov, JE Posey - PloS one, 2012 - journals.plos.org
Fluoroquinolone antibiotics are among the most potent second-line drugs used for treatment
of multidrug-resistant tuberculosis (MDR TB), and resistance to this class of antibiotics is one …
of multidrug-resistant tuberculosis (MDR TB), and resistance to this class of antibiotics is one …
In-silico molecular docking and ADME/pharmacokinetic prediction studies of some novel carboxamide derivatives as anti-tubercular agents
M Abdullahi, SE Adeniji - Chemistry Africa, 2020 - Springer
Molecular docking simulation of thirty-five (35) molecules of N-(2-phenoxy) ethyl imidazo [1,
2-a] pyridine-3-carboxamide (IPA) with Mycobacterium tuberculosis target (DNA gyrase) was …
2-a] pyridine-3-carboxamide (IPA) with Mycobacterium tuberculosis target (DNA gyrase) was …
Recent advances and challenges of revolutionizing drug-resistant tuberculosis treatment
X Wei, L Yue, B Zhao, N Jiang, H Lei, X Zhai - European journal of …, 2024 - Elsevier
Tuberculosis (TB), an infectious disease induced by Mycobacterium tuberculosis, is one of
the primary public health threats all over the world. Since the prevalence of first-line anti-TB …
the primary public health threats all over the world. Since the prevalence of first-line anti-TB …