Variability in disease presentation, progression and treatment response has been a central
challenge in medicine. Although variability in host factors and genetics are important, it has …

The human gut microbiome contains the largest number of bacteria in the body and has the
potential to greatly influence metabolism, not only locally but also systemically. There is an …

Musculoskeletal diseases affect up to 20% of adults worldwide. The gut microbiome has
been implicated in inflammatory conditions, but large-scale metagenomic evaluations have …

Gut microbiota dysbiosis is associated with the development of rheumatoid arthritis (RA).
Sinomenine (SIN) is an effective immunosuppressive and anti-inflammatory drug used for …

Rheumatoid arthritis (RA) is a progressive inflammatory disorder characterized by swollen
joints, discomfort, tightness, bone degeneration and frailty. Genetic, agamogenetic and sex …

Rheumatoid arthritis (RA) is a chronic autoimmune disease characterized by progressive
polyarthritis that leads to cartilage and bone damage. Pre-clinical RA is a prolonged state …

Background Rapid advances in the past decade have shown that dysbiosis of the gut
microbiome is a key hallmark of rheumatoid arthritis (RA). Yet, the relationship between the …

Gut commensals help shape and mold host immune system and deeply influence human
health. The disease spectrum of mankind that gut microbiome may associate with is ever …

Depression is common in patients with rheumatoid arthritis (RA); however, the precise
mechanisms underlying a link between depression and RA remain unclear. Accumulating …

Rheumatoid arthritis is a chronic systemic immune-mediated disease caused by genetic and
environmental factors. It is often characterized by the generation of autoantibodies that lead …