In a healthy body, homeostatic actions of osteoclasts and osteoblasts maintain the integrity
of the skeletal system. When cellular activities of osteoclasts and osteoblasts become …

Musculoskeletal disorders (MSDs) are broadly defined as diseases or injuries of the joints,
bones, muscles, nerves, tendons, ligaments, supporting soft tissues, cartilage, and spinal …

The prevalence of metabolic bone diseases particularly osteoporosis and its precursor,
osteopenia, continue to grow as serious global health issues today. On a worldwide …

Quantitative image analysis has deep roots in the usage of positron emission tomography
(PET) in clinical and research settings to address a wide variety of diseases. It has been …

The bone-seeking properties of 18F-sodium fluoride (NaF) were first described in 1962 by
Blau and colleagues, 1 who used this positron-emitting radiotracer in skeletal scintigraphy …

Purpose [18 F] NaF PET has become an increasingly important tool in clinical practice
toward understanding and evaluating diseases and conditions in which bone metabolism is …

Background The present study aimed to investigate the clinical implication of F-18 sodium
fluoride (NaF) positron emission tomography/computed tomography (PET/CT) for assessing …

Bone remodeling is an important physiologic process for replacing old bone with newer and
healthier bone. This remodeling process requires the constant activity of osteoclasts, which …

Background: Long suspected as transcriptional noise, recently recognized, long non-coding
RNAs (lncRNAs) are emerging as an indicator, biomarker and therapy target in the …

Over the last decade, major advances have been made in PET imaging, including the
introduction of hybrid PET/computed tomography (CT) and PET/MR imaging systems …