The pedunculopontine nucleus (PPN) has long been considered an interface between the
basal ganglia and motor systems, and its ability to regulate arousal states puts the PPN in a …

Parkinson's disease (PD) is a neurodegenerative disorder characterized by selective loss of
dopaminergic neurons in the substantia nigra pars compacta (SNpc) region of the midbrain …

The mesencephalic locomotor region (MLR) serves as an interface between higher-order
motor systems and lower motor neurons. The excitatory module of the MLR is composed of …

Assimilation of novel strategies into a consolidated action repertoire is a crucial function for
behavioral adaptation and cognitive flexibility. Acetylcholine in the striatum plays a pivotal …

Cholinergic neurons of the brainstem have traditionally been associated with a role in
wakefulness as part of the reticular activating system, but their function cannot be explained …

In the last decade, scientific and clinical interest in the pedunculopontine nucleus (PPN) has
grown dramatically. This growth is largely a consequence of experimental work …

The evolution of novel motor behaviors requires modifications in the central pattern
generators (CPGs) controlling muscle activity. How such changes gradually lead to novel …

To bridge the gap between preclinical cellular models of disease and in vivo imaging of
human cognitive network dynamics, there is a pressing need for informative biophysical …

Cortical recordings of task-induced oscillations following subanaesthetic ketamine
administration demonstrate alterations in amplitude, including increases at high-frequencies …

OBJECTIVE Neuronal loss within the cholinergic nucleus basalis of Meynert (nbM)
correlates with cognitive decline in dementing disorders such as Alzheimer's disease and …