New Imidazo[4,5‐c]pyridine‐piperidine Hybrids as Potential Anti‐cancer Agents and In‐Silico Studies
Abstract Design and synthesis of a series of novel hybrid molecules that combine Imidazo [4,
5‐c] pyridines with piperdines are presented in this paper. Total 17 derivatives were …
5‐c] pyridines with piperdines are presented in this paper. Total 17 derivatives were …
Pd-catalyzed synthesis, characterization, and biological evaluations of pyrazole derivatives: DFT, molecular modelling and antioxidant studies
Abstract Using Pd (PPh 3) 4 as a catalyst, a new series of coupling products (5a–5l)
synthesized from pyrazole derivatives (4a-4c) and substituted boronic acids. Afterward, 1 H …
synthesized from pyrazole derivatives (4a-4c) and substituted boronic acids. Afterward, 1 H …
Chlordiazepoxide against signalling, receptor and regulatory proteins of breast cancer: a structure-based in-silico approach
Among the most prevalent forms of cancer are breast, lung, colon-rectum, and prostate
cancers, and breast cancer is a major global health challenge, contributing to 2.26 million …
cancers, and breast cancer is a major global health challenge, contributing to 2.26 million …
Synthesis, characterization, mechanistic study, in-vitro and in-silico evaluation of antibacterial and antioxidant activities of novel pyrazole-pyrazoline hybrid systems
N Barghady, M Chalkha, I Yamari, N Aflak… - Journal of Molecular …, 2024 - Elsevier
This study describes the synthesis, characterization, and in vitro as well as in silico
assessment of the biological activity of a new series of hybrid molecules. These target …
assessment of the biological activity of a new series of hybrid molecules. These target …
Novel Coumarin‐Pyrazole‐Thiazoles Hybrids: Synthesis, Anticancer Activity, Molecular Docking and In Silico ADMET prediction Studies
AK Alsolimani, TE Ali, MA Assiri, AA Shati… - …, 2024 - Wiley Online Library
A novel series of coumarin‐pyrazole‐thiazoles hybrids was designed. The methodology
depended on a simple condensation reaction of 3‐(2‐oxo‐2H‐chromen‐3‐yl)‐1‐phenyl‐1H …
depended on a simple condensation reaction of 3‐(2‐oxo‐2H‐chromen‐3‐yl)‐1‐phenyl‐1H …
Innovative Synthesis of 3, 5-Disubstituted Pyrazoline with Heterocyclic System for Hybrid Development
A Chauhan, Salahuddin, A Mazumder… - Letters in Organic …, 2024 - benthamdirect.com
The synthesis of 3, 5-disubstituted pyrazolines, integrated with heterocyclic systems,
represents a crucial area of chemical research due to their pharmacological and biological …
represents a crucial area of chemical research due to their pharmacological and biological …
Repurposing the antihistamine drug bilastine as an anti-cancer metallic drug entity: synthesis and single-crystal X-ray structure analysis of metal-based bilastine and …
F Arjmand, S Tabassum - Dalton Transactions, 2024 - pubs.rsc.org
Bilastine (BLA), 2-(4-(2-(4-(1-(2-ethoxyethyl)-1H-benzo [d] imidazole-2-yl)-piperidin-1-yl)-
ethyl)-phenyl)-2-methylpropanoic acid, is an active antihistamine drug. With the idea of …
ethyl)-phenyl)-2-methylpropanoic acid, is an active antihistamine drug. With the idea of …
Explore new quinoxaline pharmacophore tethered sulfonamide fragments as in vitro α‐glucosidase, α‐amylase, and acetylcholinesterase inhibitors with ADMET and …
A new series of quinoxaline‐sulfonamide derivatives 3–12 were synthesized using fragment‐
based drug design by reaction of quinoxaline sulfonyl chloride (QSC) with different amines …
based drug design by reaction of quinoxaline sulfonyl chloride (QSC) with different amines …
Structure-Based In Silico Approaches Reveal IRESSA as a Multitargeted Breast Cancer Regulatory, Signalling, and Receptor Protein Inhibitor
HH Almasoudi, MM Mashraqi, SA Alshamrani… - Pharmaceuticals, 2024 - mdpi.com
Breast cancer begins in the breast cells, mainly impacting women. It starts in the cells that
line the milk ducts or lobules responsible for producing milk and can spread to nearby …
line the milk ducts or lobules responsible for producing milk and can spread to nearby …
Cheminformatics approach for identification of N-HyMenatPimeMelly as a novel potential ligand against RAS and renal chloride channel
Some angiotensin receptor (AR) blockers interfere with the renal chloride channel (ClC-K),
which plays an important role in urine concentration. Identifying ligands targeting this …
which plays an important role in urine concentration. Identifying ligands targeting this …