Efficient and regulated nucleocytoplasmic trafficking of macromolecules to the correct
subcellular compartment is critical for proper functions of the eukaryotic cell. The majority of …

Ubiquitination, an important type of protein posttranslational modification (PTM), plays a
crucial role in controlling substrate degradation and subsequently mediates the “quantity” …

Background YAP activation is crucial for cancer development including colorectal cancer
(CRC). Nevertheless, it remains unclear whether N6-Methyladenosine (m 6 A) modified …

The epigenetic modifications of histones are versatile marks that are intimately connected to
development and disease pathogenesis including human cancers. In this review, we will …

The Hippo signalling pathway has emerged as a major player in many aspects of liver
biology, such as development, cell fate determination, homeostatic function and …

The Hippo pathway remains a central focus in both basic and translational research and is a
key modulator of developmental biology. Dysregulation of the pathway is associated with a …

Drug resistance is a major challenge in cancer treatment. Emerging evidence indicates that
deregulation of YAP/TAZ signaling may be a major mechanism of intrinsic and acquired …

Studies of the regenerative capacity of the liver have converged on the Hippo pathway, a
serine/threonine kinase cascade discovered in Drosophila and conserved from unicellular …

The Hippo-Yes-associated protein (YAP) signaling network plays a central role as an
integrator of signals that control cellular proliferation and differentiation. The past several …

Liver cancer, hepatocellular carcinoma (HCC) in particular, is one of the deadliest cancers
worldwide. Although the etiologies for liver oncogenesis are relatively well defined, the exact …