Acute and chronic pain complaints, although common, are generally poorly served by
existing therapies. This unmet clinical need reflects a failure to develop novel classes of …

The large Trp gene family encodes transient receptor potential (TRP) proteins that form
novel cation-selective ion channels. In mammals, 28 Trp channel genes have been …

Local anaesthetic agents suppress action potentials in excitable tissues by blocking voltage-
gated Na+ channels. In doing so, they inhibit action potentials in nociceptive fibres and so …

The transient receptor potential ankyrin subtype 1 protein (TRPA1) is a nonselective cation
channel permeable to Ca 2+, Na+, and K+. TRPA1 is a promiscuous chemical nocisensor …

Local anesthetics have been used clinically for more than a century, but new insights into
their mechanisms of action and their interaction with biological systems continue to surprise …

The capsaicin receptor TRPV1 ion channel is a polymodal nociceptor that responds to heat
with exquisite sensitivity through an unknown mechanism. Here we report the identification …

Transient receptor potential vanilloid (TRPV) channels are activated by ligands and heat
and are involved in various physiological processes. In contrast to the architecturally related …

The sensory nervous and immune systems, historically considered autonomous, actually
work in concert to promote host defense and tissue homeostasis. These systems interact …

Capsaicin is a naturally occurring alkaloid derived from chili pepper that is responsible for its
hot pungent taste. Capsaicin is known to exert multiple pharmacological actions, including …

OCT1 is the most highly expressed cation transporter in the liver and affects
pharmacokinetics and pharmacodynamics. Newly marketed drugs have previously been …