Alkaloid biosynthesis: metabolism and trafficking

J Ziegler, PJ Facchini - Annu. Rev. Plant Biol., 2008 - annualreviews.org
Alkaloids represent a highly diverse group of compounds that are related only by the
occurrence of a nitrogen atom in a heterocyclic ring. Plants are estimated to produce …

A raison d'être for two distinct pathways in the early steps of plant isoprenoid biosynthesis?

A Hemmerlin, JL Harwood, TJ Bach - Progress in lipid research, 2012 - Elsevier
When compared to other organisms, plants are atypical with respect to isoprenoid
biosynthesis: they utilize two distinct and separately compartmentalized pathways to build …

Production and engineering of terpenoids in plant cell culture

SC Roberts - Nature chemical biology, 2007 - nature.com
Terpenoids are a diverse class of natural products that have many functions in the plant
kingdom and in human health and nutrition. Their chemical diversity has led to the discovery …

Hairy root culture for mass-production of high-value secondary metabolites

S Srivastava, AK Srivastava - Critical reviews in biotechnology, 2007 - Taylor & Francis
Plant cell cultivations are being considered as an alternative to agricultural processes for
producing valuable phytochemicals. Since many of these products (secondary metabolites) …

Monoterpenoid indole alkaloids biosynthesis and its regulation in Catharanthus roseus: a literature review from genes to metabolites

Q Pan, NR Mustafa, K Tang, YH Choi… - Phytochemistry reviews, 2016 - Springer
As the only source for the low-abundance antitumor agents vinblastine and vincristine,
Catharanthus roseus is highly valued and has been studied extensively as a model for …

Hairy root and its application in plant genetic engineering

ZB Hu, M Du - Journal of integrative plant biology, 2006 - Wiley Online Library
Agrobacterium rhizogenes Conn. causes hairy root disease in plants. Hairy root‐infected A.
rhizogenes is characterized by a high growth rate and genetic stability. Hairy root cultures …

Hairy root culture technology: applications, constraints and prospect

S Gantait, E Mukherjee - Applied Microbiology and Biotechnology, 2021 - Springer
Hairy root (HR) culture, a successful biotechnology combining in vitro tissue culture with
recombinant DNA machinery, is intended for the genetic improvement of plants. This …

Opium poppy and Madagascar periwinkle: model non‐model systems to investigate alkaloid biosynthesis in plants

PJ Facchini, V De Luca - The Plant Journal, 2008 - Wiley Online Library
Alkaloids represent a large and diverse group of compounds that are related by the
occurrence of a nitrogen atom within a heterocyclic backbone. Unlike other types of …

Chlorophyllase is a rate-limiting enzyme in chlorophyll catabolism and is posttranslationally regulated

S Harpaz-Saad, T Azoulay, T Arazi… - The Plant …, 2007 - academic.oup.com
Chlorophyll is a central player in harvesting light energy for photosynthesis, yet the rate-
limiting steps of chlorophyll catabolism and the regulation of the catabolic enzymes remain …

Catharanthus terpenoid indole alkaloids: biosynthesis and regulation

M El-Sayed, R Verpoorte - Phytochemistry Reviews, 2007 - Springer
Catharanthus roseus is still the only source for the powerful antitumour drugs vinblastine
and vincristine. Some other pharmaceutical compounds from this plant, ajmalicine and …