Mitochondria are a distinguishing feature of eukaryotic cells. Best known for their critical
function in energy production via oxidative phosphorylation (OXPHOS), mitochondria are …

Inflammation represents a comprehensive host response to external stimuli for the purpose
of eliminating the offending agent, minimizing injury to host tissues and fostering repair of …

Cystic fibrosis (CF), caused by biallelic inactivating mutations in the cystic fibrosis
transmembrane conductance regulator (CFTR) gene, has recently been categorized as a …

Peripheral muscle dysfunction is an important systemic consequence of cystic fibrosis (CF)
with major clinical implications, such as exercise intolerance and reduced quality of life …

Cystic fibrosis is a hereditary disease that mainly affects secretory organs in humans. It is
caused by mutations in the gene encoding CFTR with the most common phenylalanine …

Cystic fibrosis (CF) is the most common genetic disorder that causes a significant damage in
secretory epithelial cells due to the defective ion flux across the cystic fibrosis …

The specific role of the chloride anion (Cl−) as a signalling effector or second messenger
has been increasingly recognized in recent years. It could represent a key factor in the …

Abstract Objective Elexacaftor/Tezacaftor/Ivacaftor is a cystic fibrosis transmembrane
conductance regulator (CFTR) modulator with the potential to improve exercise capacity …

Introduction Oxidative stress may play an important role in the pathophysiology of cystic
fibrosis (CF). This review aimed to quantify CF-related redox imbalances. Methods …

Background Cystic fibrosis (CF) remains without a definitive cure. Novel therapeutics
targeting the causative defect in the cystic fibrosis transmembrane conductance regulator …