Reconsidering animal models used to study autism spectrum disorder: Current state and optimizing future

JL Silverman, A Thurm, SB Ethridge… - Genes, brain and …, 2022 - Wiley Online Library
Neurodevelopmental disorders (NDDs), including autism spectrum disorder (ASD) and
intellectual disability (ID), are pervasive, often lifelong disorders, lacking evidence‐based …

Social skills deficits in autism spectrum disorder: potential biological origins and progress in developing therapeutic agents

RE Frye - CNS drugs, 2018 - Springer
Autism spectrum disorder is defined by two core symptoms: a deficit in social communication
and the presence of repetitive behaviors and/or restricted interests. Currently, there is no US …

Zebrafish modeling of autism spectrum disorders, current status and future prospective

A Tayanloo-Beik, SK Hamidpour, M Abedi… - Frontiers in …, 2022 - frontiersin.org
Autism spectrum disorder (ASD) refers to a complicated range of childhood
neurodevelopmental disorders which can occur via genetic or non-genetic factors. Clinically …

A review of oxytocin and arginine-vasopressin receptors and their modulation of autism spectrum disorder

I Cataldo, A Azhari, G Esposito - Frontiers in molecular neuroscience, 2018 - frontiersin.org
Oxytocin (OXT) and arginine-vasopressin (AVP) play a key regulatory part in social and
affiliative behaviors; two aspects highly compromised in Autism Spectrum Disorder (ASD) …

Validation of prenatal versus postnatal valproic acid rat models of autism: A behavioral and neurobiological study

EM Elnahas, SA Abuelezz, MI Mohamad… - Progress in Neuro …, 2021 - Elsevier
Despite the increasing prevalence of autism spectrum disorder (ASD), there is still a
deficiency in understanding its exact pathophysiology and treatment, therefore validation of …

[HTML][HTML] Understanding autism spectrum disorders with animal models: applications, insights, and perspectives

Z Li, YX Zhu, LJ Gu, Y Cheng - Zoological research, 2021 - ncbi.nlm.nih.gov
Autism spectrum disorder (ASD) is typically characterized by common deficits in social skills
and repetitive/stereotyped behaviors. It is widely accepted that genetic and environmental …

Interplay between peripheral and central inflammation in autism spectrum disorders: possible nutritional and therapeutic strategies

C Cristiano, A Lama, F Lembo, MP Mollica… - Frontiers in …, 2018 - frontiersin.org
Pre-and post-natal factors can affect brain development and function, impacting health
outcomes with particular relevance to neurodevelopmental diseases, such as autism …

Early postnatal handling alters social behavior, learning, and memory of pre-and postnatal VPA-induced rat models of autism in a context-based manner

SSV Shahrbabaki, H Jonaidi, V Sheibani… - Physiology & Behavior, 2022 - Elsevier
Early life events are known to greatly affect brain development, cortical neurogenesis, and
Hypothalamic-pituitary-adrenal activity. Mainly characterized by impairment in social …

Quantitative rodent brain receptor imaging

K Herfert, JG Mannheim, L Kuebler, S Marciano… - Molecular Imaging and …, 2020 - Springer
Positron emission tomography (PET) is a non-invasive imaging technology employed to
describe metabolic, physiological, and biochemical processes in vivo. These include …

Autism spectrum disorder and miRNA: an overview of experimental models

G Schepici, E Cavalli, P Bramanti, E Mazzon - Brain Sciences, 2019 - mdpi.com
Autism spectrum disorder (ASD) is a complex neuropsychiatric disorder characterized by
deficits in social interactions, communication, language, and in a limited repertoire of …