Leprosy: clinical and immunopathological characteristics

LAR Froes, MN Sotto, MAB Trindade - Anais Brasileiros de …, 2022 - SciELO Brasil
Leprosy, a disease caused by Mycobacterium leprae, has polymorphic neurocutaneous
manifestations strongly correlated with the host immune response. Peripheral neural …

Innate immune responses in leprosy

RO Pinheiro, V Schmitz, BJA Silva, AA Dias… - Frontiers in …, 2018 - frontiersin.org
Leprosy is an infectious disease that may present different clinical forms depending on host
immune response to Mycobacterium leprae. Several studies have clarified the role of …

Immunology of leprosy

LAR Froes Jr, MAB Trindade… - International Reviews of …, 2022 - Taylor & Francis
Leprosy is a disease caused by Mycobacterium leprae (ML) with diverse clinical
manifestations, which are strongly correlated with the host's immune response. Skin lesions …

[HTML][HTML] The neurological impact of leprosy: manifestations and treatment approaches

A Calderone, MC Aloisi, C Casella, S Fiannacca… - Neurology …, 2024 - mdpi.com
Background and Objectives: Leprosy primarily affects peripheral nerves, leading to
significant neurological complications such as polyneuritis, mononeurosis, and autonomic …

Effectiveness of 32 versus 20 weeks of prednisolone in leprosy patients with recent nerve function impairment: A randomized controlled trial

I Wagenaar, E Post, W Brandsma… - PLoS Neglected …, 2017 - journals.plos.org
Background While prednisolone is commonly used to treat recent nerve function impairment
(NFI) in leprosy patients, the optimal treatment duration has not yet been established. In this …

Targeting differential roles of tumor necrosis factor receptors as a therapeutic strategy for glaucoma

L Lambuk, S Ahmad, MZ Sadikan, NA Nordin… - Frontiers in …, 2022 - frontiersin.org
Glaucoma is an irreversible sight-threatening disorder primarily due to elevated intraocular
pressure (IOP), leading to retinal ganglion cell (RGC) death by apoptosis with subsequent …

Modulation of the Response to Mycobacterium leprae and Pathogenesis of Leprosy

N Cabral, V de Figueiredo, M Gandini… - Frontiers in …, 2022 - frontiersin.org
The initial infection by the obligate intracellular bacillus Mycobacterium leprae evolves to
leprosy in a small subset of the infected individuals. Transmission is believed to occur …

Leprosy reactions and neuropathic pain in pure neural leprosy in a reference center in rio de janeiro–Brazil

IJR Pitta, MA Hacker, RT Vital, LR Andrade… - Frontiers in …, 2022 - frontiersin.org
Introduction Leprosy reactions are complications that can occur before, during, or after
multidrug therapy (MDT) and are considered a major cause of nerve damage. Neuritis is an …

Gene Expression Profile of Mycobacterium leprae Contribution in the Pathology of Leprosy Neuropathy

BJ Souza, MA Mendes, GM Sperandio da Silva… - Frontiers in …, 2022 - frontiersin.org
Peripheral neuropathy is the main cause of physical disability in leprosy patients.
Importantly, the extension and pattern of peripheral damage has been linked to how the host …

Case report: a case series of immunobiological therapy (Anti-TNF-α) for patients with erythema nodosum leprosum

AFM Mendes, CM Gomes, PS Kurizky… - Frontiers in Medicine, 2022 - frontiersin.org
Patients with leprosy may experience a chronic and severe type II leprosy reaction (ENL)
erythema nodosum leprosum that may not respond to thalidomide and systemic …