A number of mutations to members of several CNS potassium (K) channel families have
been identified which result in rare forms of neonatal onset epilepsy, or syndromes of which …

The cardiac action potential is critical to the production of a synchronized heartbeat. This
electrical impulse is governed by the intricate activity of cardiac ion channels, among them …

Summary Kv7 (KCNQ) voltage-gated potassium channels control excitability in the brain,
heart, and ear. Calmodulin (CaM) is crucial for Kv7 function, but how this calcium sensor …

Voltage-gated ion channels feature voltage sensor domains (VSDs) that exist in three
distinct conformations during activation: resting, intermediate, and activated. Experimental …

Abstract KCNQ family K+ channels (KCNQ1-5) in the heart, nerve, epithelium and ear
require phosphatidylinositol 4, 5-bisphosphate (PIP2) for voltage dependent activation …

Phosphatidylinositol 4, 5-bisphosphate (PIP 2) in the plasma membrane regulates the
function of many ion channels, including M-type (potassium voltage-gated channel …

Neuronal K v 7/KCNQ channels are voltage-gated potassium channels composed of K v
7.2/KCNQ2 and K v 7.3/KCNQ3 subunits. Enriched at the axonal membrane, they potently …

The profiles of ion currents during the cardiac action potential can be visualized by the
action potential voltage clamp technique. To obtain multiple ion current data from the same …

Calmodulin (CaM) is the principal Ca2+ sensor in eukaryotic cells, orchestrating the activity
of hundreds of proteins. Disease causing mutations at any of the three genes that encode …

KCNQ (Kv7) channels are voltage-gated, phosphatidylinositol 4, 5-bisphosphate-(PIP 2-)
modulated potassium channels that play essential roles in regulating the activity of neurons …