Recent advances on cell culture platforms for in vitro drug screening and cell therapies: from conventional to microfluidic strategies

BD Cardoso, EMS Castanheira… - Advanced …, 2023 - Wiley Online Library
The clinical translations of drugs and nanomedicines depend on coherent pharmaceutical
research based on biologically accurate screening approaches. Since establishing the 2D in …

Sensors based on bio and biomimetic receptors in medical diagnostic, environment, and food analysis

AN Kozitsina, TS Svalova, NN Malysheva… - Biosensors, 2018 - mdpi.com
Analytical chemistry is now developing mainly in two areas: automation and the creation of
complexes that allow, on the one hand, for simultaneously analyzing a large number of …

Micro total analysis systems: fundamental advances and biological applications

CT Culbertson, TG Mickleburgh… - Analytical …, 2014 - ACS Publications
It has been more than 20 years since the first micro total analysis systems (μTAS) papers
were published. Initial reports of these devices, which are also commonly referred to as …

High-throughput screening approaches and combinatorial development of biomaterials using microfluidics

D Barata, C van Blitterswijk, P Habibovic - Acta biomaterialia, 2016 - Elsevier
From the first microfluidic devices used for analysis of single metabolic by-products to highly
complex multicompartmental co-culture organ-on-chip platforms, efforts of many …

Three-dimensional cancer models mimic cell–matrix interactions in the tumour microenvironment

D Herrmann, JRW Conway, C Vennin… - …, 2014 - academic.oup.com
Basic in vitro systems can be used to model and assess complex diseases, such as cancer.
Recent advances in this field include the incorporation of multiple cell types and …

Cytotoxic cobalt (III) Schiff base complexes: in vitro anti-proliferative, oxidative stress and gene expression studies in human breast and lung cancer cells

B Gowdhami, Y Manojkumar, RTV Vimala, V Ramya… - BioMetals, 2022 - Springer
Increasing cancer drug chemo-resistance, especially in the treatment of breast and lung
cancers, alarms the immediate need of newer and effective anticancer drugs. Until now …

Organ-on-a-Chip: Design and simulation of various microfluidic channel geometries for the influence of fluid dynamic parameters

F Pisapia, W Balachandran, M Rasekh - Applied Sciences, 2022 - mdpi.com
Shear stress, pressure, and flow rate are fluid dynamic parameters that can lead to changes
in the morphology, proliferation, function, and survival of many cell types and have a …

Organ-tumor-on-a-chip for chemosensitivity assay: a critical review

N Kashaninejad, MR Nikmaneshi, H Moghadas… - Micromachines, 2016 - mdpi.com
With a mortality rate over 580,000 per year, cancer is still one of the leading causes of death
worldwide. However, the emerging field of microfluidics can potentially shed light on this …

Heart-on-a-chip based on stem cell biology

E Jastrzebska, E Tomecka, I Jesion - Biosensors and Bioelectronics, 2016 - Elsevier
Heart diseases are one of the main causes of death around the world. The great challenge
for scientists is to develop new therapeutic methods for these types of ailments. Stem cells …

3D printed microfluidic chip for multiple anticancer drug combinations

X Chen, H Chen, D Wu, Q Chen, Z Zhou… - Sensors and Actuators B …, 2018 - Elsevier
Multi-drug combinations therapy is a promising method in the fight against cancer cells. Multi-
drug combinations cannot be practically elucidated using conventional devices owing to …