High-throughput methods in the discovery and study of biomaterials and materiobiology

L Yang, S Pijuan-Galito, HS Rho, AS Vasilevich… - Chemical …, 2021 - ACS Publications
The complex interaction of cells with biomaterials (ie, materiobiology) plays an increasingly
pivotal role in the development of novel implants, biomedical devices, and tissue …

Molecularly imprinted polymers as receptors for assays of antibiotics

N Tarannum, OD Hendrickson, S Khatoon… - Critical reviews in …, 2020 - Taylor & Francis
The use of excessive antibiotics in medical treatment and animal breeding has led to their
prevalence in the environment and foods. Thereby, rapid, cheap, and sustainable …

[HTML][HTML] The impact of surface chemistry modification on macrophage polarisation

HM Rostam, S Singh, F Salazar, P Magennis, A Hook… - Immunobiology, 2016 - Elsevier
Macrophages are innate immune cells that have a central role in combating infection and
maintaining tissue homeostasis. They exhibit remarkable plasticity in response to …

Discovery of (meth) acrylate polymers that resist colonization by fungi associated with pathogenesis and biodeterioration

C Vallieres, AL Hook, Y He, VC Crucitti… - Science …, 2020 - science.org
Fungi have major, negative socioeconomic impacts, but control with bioactive agents is
increasingly restricted, while resistance is growing. Here, we describe an alternative fungal …

[HTML][HTML] A defined synthetic substrate for serum-free culture of human stem cell derived cardiomyocytes with improved functional maturity identified using …

AK Patel, AD Celiz, D Rajamohan, DG Anderson… - Biomaterials, 2015 - Elsevier
Cardiomyocytes from human stem cells have applications in regenerative medicine and can
provide models for heart disease and toxicity screening. Soluble components of the culture …

A non-woven path: electrospun poly (lactic acid) scaffolds for kidney tissue engineering

TP Burton, A Callanan - Tissue Engineering and Regenerative Medicine, 2018 - Springer
Chronic kidney disease is a major global health problem affecting millions of people; kidney
tissue engineering provides an opportunity to better understand this disease, and has the …

Combinatorial approaches in post-polymerization modification for rational development of therapeutic delivery systems

Y Zhong, BJ Zeberl, X Wang, J Luo - Acta biomaterialia, 2018 - Elsevier
The combinatorial polymer library approach has been proven to be effective for the
optimization of therapeutic delivery systems. The library of polymers with chemical diversity …

Computer Vision for Substrate Detection in High‐Throughput Biomaterial Screens Using Bright‐Field Microscopy

R Owen, A Nasir, MH Amer, C Nie… - Advanced Intelligent …, 2024 - Wiley Online Library
High‐throughput screening (HTS) can be used when ab initio information is unavailable for
rational design of new materials, generating data on properties such as chemistry and …

Chemically diverse polymer microarrays and high throughput surface characterisation: a method for discovery of materials for stem cell culture

AD Celiz, JGW Smith, AK Patel, R Langer… - Biomaterials …, 2014 - pubs.rsc.org
Materials discovery provides the opportunity to identify novel materials that are tailored to
complex biological environments by using combinatorial mixing of monomers to form large …

[HTML][HTML] Multivariate ToF-SIMS image analysis of polymer microarrays and protein adsorption

AL Hook, PM Williams, MR Alexander, DJ Scurr - Biointerphases, 2015 - pubs.aip.org
The complexity of hyperspectral time of flight secondary ion mass spectrometry (ToF-SIMS)
datasets makes their subsequent analysis and interpretation challenging, and is often an …