Electrospun nanofibers as dressings for chronic wound care: advances, challenges, and future prospects

M Abrigo, SL McArthur… - Macromolecular bioscience, 2014 - Wiley Online Library
Chronic non‐healing wounds show delayed and incomplete healing processes and in turn
expose patients to a high risk of infection. Treatment currently focuses on dressings that …

Therapy of infected wounds: overcoming clinical challenges by advanced drug delivery systems

P Kaiser, J Wächter, M Windbergs - Drug Delivery and Translational …, 2021 - Springer
In recent years, the incidence of infected wounds is steadily increasing, and so is the clinical
as well as economic interest in effective therapies. These combine reduction of pathogen …

[HTML][HTML] Ag modified mesoporous bioactive glass nanoparticles for enhanced antibacterial activity in 3D infected skin model

K Zheng, P Balasubramanian, TE Paterson… - Materials Science and …, 2019 - Elsevier
Bioactive glasses (BG) are versatile materials for various biomedical applications, including
bone regeneration and wound healing, due to their bone bonding, antibacterial, osteogenic …

Repair Process Impairment by Pseudomonas aeruginosa in Epithelial Tissues: Major Features and Potential Therapeutic Avenues

M Ruffin, E Brochiero - Frontiers in cellular and infection microbiology, 2019 - frontiersin.org
Epithelial tissues protecting organs from the environment are the first-line of defense against
pathogens. Therefore, efficient repair mechanisms after injury are crucial to maintain …

Development of a Full-Thickness Human Skin Equivalent In Vitro Model Derived from TERT-Immortalized Keratinocytes and Fibroblasts

CMA Reijnders, A van Lier, S Roffel… - … Engineering Part A, 2015 - liebertpub.com
Currently, human skin equivalents (HSEs) used for in vitro assays (eg, for wound healing)
make use of primary human skin cells. Limitations of primary keratinocytes and fibroblasts …

The T6SSs of Pseudomonas aeruginosa Strain PAO1 and Their Effectors: Beyond Bacterial-Cell Targeting

TG Sana, B Berni, S Bleves - Frontiers in cellular and infection …, 2016 - frontiersin.org
Pseudomonas aeruginosa is an opportunistic pathogen responsible for many diseases such
as chronic lung colonization in cystic fibrosis patients and acute infections in hospitals. The …

A review of recent advances in drug loading, mathematical modeling and applications of hydrogel drug delivery systems

X Hu, C Zhang, Y Xiong, S Ma, C Sun, W Xu - Journal of Materials Science, 2024 - Springer
In recent years, the medical community has been drawn to the attention of hydrogels due to
their favorable mechanical properties, lower cytotoxicity, and excellent biocompatibility …

Development of an experimental ex vivo wound model to evaluate antimicrobial efficacy of topical formulations

MÅ Andersson, LB Madsen, A Schmidtchen… - International journal of …, 2021 - mdpi.com
Wound infections are considered a major cause for wound-associated morbidity. There is a
high demand for alternative, robust, and affordable methods that can provide relatable and …

In vitro models for evaluating safety and efficacy of novel technologies for skin drug delivery

V Planz, CM Lehr, M Windbergs - Journal of Controlled Release, 2016 - Elsevier
For preclinical testing of novel therapeutics, predictive in vitro models of the human skin are
required to assess efficacy, absorption and safety. Simple as well as more sophisticated …

Imitating the microenvironment of native biofilms using nanofibrous scaffolds to emulate chronic wound infections

J Wächter, PK Vestweber, N Jung… - Journal of Materials …, 2023 - pubs.rsc.org
Three-dimensional scaffolds of electrospun fibers are widely investigated for in vitro human
tissue engineering, but to date, their application in the cultivation of bacterial biofilms has …