Microbial natural products are a tremendous source of new bioactive chemical entities for
drug discovery. Next generation sequencing has revealed an unprecedented genomic …

The available literature on the secondary or nonessential metabolites of the streptomycetes
bacteria suggests that there may be poorly expressed or “cryptic” compounds that have yet …

Highlights•Advanced genomic manipulation tools in actinomycetes enable streamlined
engineering of primary and secondary metabolism.•Advances in engineering of …

Actinobacteria are among the most prolific sources of medically and agriculturally important
compounds, derived from their biosynthetic gene clusters (BGCs) for specialized …

Abstract Cyclic dimeric 3′-5′ guanosine monophosphate, c-di-GMP, is a ubiquitous
second messenger controlling diverse cellular processes in bacteria. In streptomycetes, c-di …

Porphyromonas gingivalis is a Gram-negative pathogenic bacterium associated with chronic
periodontitis. The development of a chimeric peptide-based vaccine targeting this pathogen …

Nucleocidin is one of the very few natural products known to contain fluorine. Mysteriously,
the nucleocidin producer Streptomyces calvus ATCC 13382 has not been observed to …

Teicoplanin (Tcp) is a clinically relevant glycopeptide antibiotic (GPA) that is produced by
the actinobacterium Actinoplanes teichomyceticus. Tcp is a front-line therapy for treating …

Concern over the reports of antibiotic‐resistant bacterial infections in hospitals and in the
community has been publicized in the media, accompanied by comments on the risk that we …

Members of actinobacterial genus Streptomyces possess a sophisticated life cycle and are
the deepest source of bioactive secondary metabolites. Although morphogenesis and …