Staphylococcus aureus Secreted Toxins and Extracellular Enzymes

K Tam, VJ Torres - Microbiology spectrum, 2019 - Am Soc Microbiol
Staphylococcus aureus is a formidable pathogen capable of causing infections in different
sites of the body in a variety of vertebrate animals, including humans and livestock. A major …

Bacterial proteases and virulence

D Frees, L Brøndsted, H Ingmer - Regulated proteolysis in microorganisms, 2013 - Springer
Bacterial pathogens rely on proteolysis for variety of purposes during the infection process.
In the cytosol, the main proteolytic players are the conserved Clp and Lon proteases that …

What Makes a Bacterial Species Pathogenic?:Comparative Genomic Analysis of the Genus Leptospira

DE Fouts, MA Matthias, H Adhikarla… - PLoS neglected …, 2016 - journals.plos.org
Leptospirosis, caused by spirochetes of the genus Leptospira, is a globally widespread,
neglected and emerging zoonotic disease. While whole genome analysis of individual …

Staphylococcus aureus metalloprotease aureolysin cleaves complement C3 to mediate immune evasion

AJ Laarman, M Ruyken, CL Malone… - The Journal of …, 2011 - journals.aai.org
Complement is one of the first host defense barriers against bacteria. Activated complement
attracts neutrophils to the site of infection and opsonizes bacteria to facilitate phagocytosis …

Staphopains modulate Staphylococcus aureus biofilm integrity

JM Mootz, CL Malone, LN Shaw… - Infection and …, 2013 - Am Soc Microbiol
Staphylococcus aureus is a known cause of chronic biofilm infections that can reside on
medical implants or host tissue. Recent studies have demonstrated an important role for …

Staphylococcal proteases aid in evasion of the human complement system

M Jusko, J Potempa, T Kantyka, E Bielecka… - Journal of innate …, 2014 - karger.com
Staphylococcus aureus is an opportunistic pathogen that presents severe health care
concerns due to the prevalence of multiple antibiotic-resistant strains. New treatment …

Extracellular metalloproteases from bacteria

JW Wu, XL Chen - Applied microbiology and biotechnology, 2011 - Springer
Bacterial extracellular metalloproteases (BEMPs) are a large group of metal-containing
proteases secreted by heterotrophic bacteria. In this review, the diversity, structural …

Inducible expression of a resistance-nodulation-division-type efflux pump in Staphylococcus aureus provides resistance to linoleic and arachidonic acids

H Alnaseri, B Arsic, JET Schneider… - Journal of …, 2015 - Am Soc Microbiol
Although Staphylococcus aureus is exposed to antimicrobial fatty acids on the skin, in nasal
secretions, and in abscesses, a specific mechanism of inducible resistance to this important …

Interaction of host and Staphylococcus aureus protease-system regulates virulence and pathogenicity

V Singh, UJ Phukan - Medical Microbiology and Immunology, 2019 - Springer
Staphylococcus aureus causes various health care-and community-associated infections as
well as certain chronic TH2 driven inflammatory diseases. It is a potent pathogen with …

Extracellular proteases from halophiles: diversity and application challenges

C Nwankwo, J Hou, HL Cui - Applied Microbiology and Biotechnology, 2023 - Springer
Halophilic extracellular proteases offer promising application in various fields. Information
on these prominent proteins including the synthesizing organisms, biochemical properties …