Major histocompatibility complex (MHC) molecules are key players in initiating immune
responses towards invading pathogens. Both MHC class I and class II genes are present in …

The classic isoforms of myelin basic protein (MBP, 14–21.5 kDa) are essential to formation
of the multilamellar myelin sheath of the mammalian central nervous system (CNS). The …

Multiple sclerosis is an immune-mediated autoimmune disease of the central nervous
system that develops in genetically susceptible individuals and likely requires environmental …

Myelination is critical for fast saltatory conduction of action potentials. Recent studies have
revealed that myelin is not a static structure as previously considered but continues to be …

The neuronal cell adhesion and recognition molecule L1 does not only 'keep cells
together'by way of homophilic and heterophilic interactions, but can also promote cell …

Normal brain development depends on tight temporal and spatial regulation of connections
between cells. Mutations in L1cam, a member of the immunoglobulin (Ig) superfamily that …

Proper brain development relies highly on protein N-glycosylation to sustain neuronal
migration, axon guidance and synaptic physiology. Impairing the N-glycosylation pathway at …

Background Dementia risk in women is higher than in men, but the molecular
neuropathology of this gender difference remains poorly defined. In this study, we used …

Fragile X syndrome (FXS) is the most common form of inherited intellectual disability and a
monogenic cause of autism spectrum disorders. Deficiencies in the fragile X messenger …

Abstract The von Economo neurons (VENs) are specialized large bipolar projection neurons
with restricted distribution in the human brain, and they are far more abundant in humans …