[HTML][HTML] Treatment of posttraumatic stress disorder: a state-of-the-art review

L Burback, S Brémault-Phillips, MJ Nijdam… - Current …, 2024 - ncbi.nlm.nih.gov
This narrative state-of-the-art review paper describes the progress in the understanding and
treatment of Posttraumatic Stress Disorder (PTSD). Over the last four decades, the scientific …

[HTML][HTML] Alleviating anxiety and taming trauma: novel pharmacotherapeutics for anxiety disorders and posttraumatic stress disorder

N Singewald, SB Sartori, A Reif, A Holmes - Neuropharmacology, 2023 - Elsevier
Psychiatric disorders associated with psychological trauma, stress and anxiety are a highly
prevalent and increasing cause of morbidity worldwide. Current therapeutic approaches …

The hippocampal FTO-BDNF-TrkB pathway is required for novel object recognition memory reconsolidation in mice

R Chang, S Zhu, J Peng, Z Lang, X Zhou, H Liao… - Translational …, 2023 - nature.com
Memory reconsolidation refers to the process by which the consolidated memory was
restored after reactivation (RA). Memory trace becomes labile after reactivation and …

Brain iron homeostasis and mental disorders

Q Wu, Q Ren, J Meng, WJ Gao, YZ Chang - Antioxidants, 2023 - mdpi.com
Iron plays an essential role in various physiological processes. A disruption in iron
homeostasis can lead to severe consequences, including impaired neurodevelopment …

Fear extinction induced by activation of PKA ameliorates anxiety-like behavior in PTSD mice

F Gao, J Wang, S Yang, M Ji, G Zhu - Neuropharmacology, 2023 - Elsevier
Prolonged exposure (PE) therapy aiming to promote fear extinction is a useful treatment for
post-traumatic stress disorder (PTSD). However, the mechanisms underlying fear extinction …

Cannabidiol impairs fear memory reconsolidation in female rats through dorsal hippocampus CB1 but not CB2 receptor interaction

JM Franzen, F Vanz, I Werle, FS Guimarães… - European …, 2022 - Elsevier
Women present increased susceptibility to anxiety-and stress-related disorders compared to
men. A potentially promising pharmacological-based strategy to regulate abnormal aversive …

Novel pharmacological targets of post-traumatic stress disorders

D Marazziti, C Carmassi, G Cappellato, I Chiarantini… - Life, 2023 - mdpi.com
Post-traumatic stress disorder (PTSD) is a psychopathological condition with a
heterogeneous clinical picture that is complex and challenging to treat. Its multifaceted …

Involvement of cannabinoid receptors and neuroinflammation in early sepsis: Implications for posttraumatic stress disorder

ME Matias, DR Radulski, TR da Silva… - International …, 2023 - Elsevier
Sepsis is associated with several comorbidities in survivors, such as posttraumatic stress
disorder (PTSD). This study investigated whether rats that survive sepsis develop the …

[HTML][HTML] Therapeutic role of psilocybin and 3, 4-methylenedioxymethamphetamine in trauma: A literature review

LN Fonseka, BK Woo - World Journal of Psychiatry, 2023 - ncbi.nlm.nih.gov
Abstract With the Food and Drug Administration designation in 2017 of 3, 4-
methylenedioxymethamphetamine (MDMA) as a breakthrough therapy in post-traumatic …

The Psychedelic Future of Post-Traumatic Stress Disorder Treatment

TG Zaretsky, KM Jagodnik, R Barsic… - Current …, 2024 - ingentaconnect.com
Post-traumatic stress disorder (PTSD) is a mental health condition that can occur following
exposure to a traumatic experience. An estimated 12 million US adults are presently affected …