Alzheimer's disease (AD) is one of the biggest human health threats due to increases in
aging of the global population. Unfortunately, drugs for treating AD have been largely …

Hypothalamic kisspeptin neurons serve as the nodal regulatory centre of reproductive
function. These neurons are subjected to a plethora of regulatory factors that ultimately affect …

In 2008, we published the first set of guidelines for standardizing research in autophagy.
Since then, this topic has received increasing attention, and many scientists have entered …

Proteolysis in eukaryotic cells is mainly mediated by the ubiquitin (Ub)-proteasome system
(UPS) and the autophagylysosome system (hereafter autophagy). The UPS is a selective …

Cancer is a major disease worldwide. Despite progress in cancer therapy, conventional
cytotoxic therapies lead to unsatisfactory long-term survival, mainly related to development …

Simple Summary The metabolism of carbohydrates and lipids is essential to meet the
diverse needs of cells. The autophagy cellular pathway is crucial for normal cellular function …

Cannabidiol (CBD), one of the compounds present in the marijuana plant, has anti-tumor
properties, but its mechanism is not well known. This study aimed to evaluate the apoptotic …

The omega-3 (ω3) fatty acid docosahexaenoic acid (DHA) can suppress inflammation,
specifically IL-1β production through poorly understood molecular mechanisms. Here, we …

Cerebral ischemia-reperfusion injury (CI/RI) remains the main cause of disability and death
in stroke patients due to lack of effective therapeutic strategies. One of the main issues …

Autophagy pathways are involved in the pathogenesis of some obesity related health
problems. As obesity is a nutrient sufficiency condition, autophagy process can be altered in …