Targeting immunometabolism against acute lung injury

L Ning, Z Shishi, W Bo, L Huiqing - Clinical Immunology, 2023 - Elsevier
Acute lung injury (ALI) and acute respiratory distress syndrome (ARDS) are life-threatening
conditions triggered by multiple intra-and extra-pulmonary injury factors, characterized by …

[HTML][HTML] Lupus Nephritis from Pathogenesis to New Therapies: An Update

A Roveta, EL Parodi, B Brezzi, F Tunesi… - International journal of …, 2024 - mdpi.com
Lupus Nephritis (LN) still represents one of the most severe complications of Systemic
Lupus Erythematosus (SLE) and a major risk factor for morbidity and mortality. However …

Elevated glucose metabolism driving pro-inflammatory response in B cells contributes to the progression of type 1 diabetes

Z Li, M Zhao, J Li, W Luo, J Huang, G Huang, Z Xie… - Clinical …, 2023 - Elsevier
Abstract Type 1 diabetes (T1D) is an autoimmune disease characterized by the immune
system's failure to maintain self-tolerance, resulting in the autoimmune destruction of …

Research progress on the clinical application and mechanism of iguratimod in the treatment of autoimmune diseases and rheumatic diseases

Z Long, L Zeng, Q He, K Yang, W Xiang, X Ren… - Frontiers in …, 2023 - frontiersin.org
Autoimmune diseases are affected by complex pathophysiology involving multiple cell
types, cytokines, antibodies and mimicking factors. Different drugs are used to improve these …

Prednisone combined with Dihydroartemisinin attenuates systemic lupus erythematosus by regulating M1/M2 balance through the MAPK signaling pathway

Y Chen, T Tao, Z Liang, X Chen, Y Xu, T Zhang… - Molecular …, 2024 - Elsevier
Objective Dihydroartemisinin (DHA) plays a very important role in various diseases.
However, the precise involvement of DHA in systemic lupus erythematosus (SLE), relation to …

Metabolic alterations in vitamin D deficient systemic lupus erythematosus patients

Y Yan, F Yu, Q Li, X Feng, L Geng, L Sun - Scientific Reports, 2024 - nature.com
Vitamin D deficiency is increasingly common in systemic lupus erythematosus (SLE)
patients and is associated with the disease activity and proteinuria. Recently, alterations in …

Trained immunity as a possible newcomer in autoinflammatory and autoimmune diseases pathophysiology

AS Beignon, C Galeotti, MM Menager… - Frontiers in …, 2023 - frontiersin.org
Autoimmune disorders have been well characterized over the years and many pathways—
but not all of them–have been found to explain their pathophysiology. Autoinflammatory …

[HTML][HTML] Unraveling the transcriptome-based network of tfh cells in primary sjogren syndrome: insights from a systems biology approach

D Luo, L Li, Y Yang, Y Ye, J Hu, Y Zong… - Frontiers in …, 2023 - frontiersin.org
Background Primary Sjogren Syndrome (pSS) is an autoimmune disease characterized by
immune cell infiltration. While the presence of follicular T helper (Tfh) cells in the glandular …

Functional consequence of Iron dyshomeostasis and ferroptosis in systemic lupus erythematosus and lupus nephritis

L Morel, Y Scindia - Clinical Immunology, 2024 - Elsevier
Systemic lupus erythematosus (SLE) and its renal manifestation Lupus nephritis (LN) are
characterized by a dysregulated immune system, autoantibodies, and injury to the renal …

Single-cell transcriptional profiling reveals aberrant gene expression patterns and cell states in autoimmune diseases

Z Liu, W Wei, J Zhang, X Yang, Z Feng, B Zhang… - Molecular …, 2024 - Elsevier
Multiple sclerosis (MS), primary Sjögren syndrome (pSS), and systemic lupus erythematosus
(SLE) share numerous clinical symptoms and serological characteristics. We analyzed …