Managing cardiovascular disease risk in patients treated with antipsychotics: a multidisciplinary approach

M Shulman, A Miller, J Misher… - Journal of multidisciplinary …, 2014 - Taylor & Francis
Background The use of antipsychotic medication in the United States and throughout the
world has greatly increased over the last fifteen years. These drugs have significant side …

Cardiovascular and cerebrovascular risk factors and events associated with second‐generation antipsychotic compared to antidepressant use in a non‐elderly adult …

CU Correll, BI Joffe, LM Rosen, TB Sullivan… - World …, 2015 - Wiley Online Library
This is a study of the metabolic and distal cardiovascular/cerebrovascular outcomes
associated with the use of second‐generation antipsychotics (SGAs) compared to …

Risk of weight gain for specific antipsychotic drugs: a meta-analysis

J Spertus, M Horvitz-Lennon, H Abing… - npj Schizophrenia, 2018 - nature.com
People with schizophrenia are at considerably higher risk of cardiometabolic morbidity than
the general population. Second-generation antipsychotic drugs contribute to that risk partly …

The use of proteomic biomarkers for improved diagnosis and stratification of schizophrenia patients

PC Guest, MK Chan, MG Gottschalk… - Biomarkers in …, 2014 - Taylor & Francis
Schizophrenia is characterized by a wide spectrum of clinical manifestations, including
strong effects on mood and behavior. Patients can also suffer from serious comorbidities …

Daily dose effects of risperidone on weight and other metabolic parameters: a prospective cohort study

M Piras, C Dubath, M Gholam, N Laaboub… - The Journal of clinical …, 2022 - psychiatrist.com
Background: Atypical antipsychotics can induce metabolic side effects, but whether they are
dose-dependent remains unclear. Objective: To assess the effect of risperidone and/or …

Clozapine, ziprasidone, and sertindole-induced morphological changes in the rat heart and their relationship to antioxidant enzymes function

A Nikolić-Kokić, N Tatalović, J Nestorov… - Journal of Toxicology …, 2018 - Taylor & Francis
Atypical antipsychotics produce severe side effects including myocarditis that may be
attributed to oxidative stress. The aim of this study was to investigate the influence of …

[HTML][HTML] Polygenic risk score for schizophrenia was not associated with glycemic level (HbA1c) in patients with non-affective psychosis: Genetic Risk and Outcome of …

TD Habtewold, MA Islam, EJ Liemburg… - Journal of …, 2020 - Elsevier
Abstract Introduction Type 2 diabetes (T2D) is a common comorbidity in patients with
schizophrenia (SCZ). The underlying pathophysiologic mechanisms are yet to be fully …

Identification of EP300 as a Key Gene Involved in Antipsychotic-Induced Metabolic Dysregulation Based on Integrative Bioinformatics Analysis of Multi-Tissue Gene …

A Martínez-Pinteño, P Gassó, L Prohens… - Frontiers in …, 2021 - frontiersin.org
Antipsychotics (APs) are associated with weight gain and other metabolic abnormalities
such as hyperglycemia, dyslipidemia and metabolic syndrome. This translational study …

Evolutions of Metabolic Parameters Following Switches of Psychotropic Drugs: A Longitudinal Cohort Study

M Piras, S Ranjbar, N Laaboub, C Grosu… - Schizophrenia …, 2023 - academic.oup.com
Background Several psychotropic drugs can induce weight gain and metabolic alterations.
The authors compared metabolic evolutions of patients switching versus continuing …

Fatty acid desaturase gene polymorphisms and metabolic measures in schizophrenia and bipolar patients taking antipsychotics

KJ Burghardt, KN Gardner, JW Johnson… - Cardiovascular …, 2013 - Wiley Online Library
Atypical antipsychotics have become a common therapeutic option in both schizophrenia
and bipolar disorder. However, these medications come with a high risk of metabolic side …