Transiently thermoresponsive polymers and their applications in biomedicine

N Vanparijs, L Nuhn, BG De Geest - Chemical Society Reviews, 2017 - pubs.rsc.org
The focus of this review is on the class of transiently thermoresponsive polymers. These
polymers are thermoresponsive, but gradually lose this property upon chemical …

Intra-myocardial biomaterial injection therapy in the treatment of heart failure: Materials, outcomes and challenges

DM Nelson, Z Ma, KL Fujimoto, R Hashizume… - Acta biomaterialia, 2011 - Elsevier
Heart failure initiated by coronary artery disease and myocardial infarction (MI) is a
widespread, debilitating condition for which there are a limited number of options to prevent …

Biodegradable elastomeric patch for treating cardiac or cardiovascular conditions

KL Fujimoto, K Tobita, J Guan, WR Wagner… - US Patent …, 2015 - Google Patents
2007-09-24 Assigned to UNIVERSITY OF PITTSBURGH-OF THE COMMONWEALTH
SYSTEM OF HIGHER EDUCATION reassignment UNIVERSITY OF PITTSBURGH-OF THE …

A fast pH‐switchable and self‐healing supramolecular hydrogel carrier for guided, local catheter injection in the infarcted myocardium

MMC Bastings, S Koudstaal, RE Kieltyka… - Advanced …, 2014 - Wiley Online Library
Minimally invasive intervention strategies after myocardial infarction use state‐of‐the‐art
catheter systems that are able to combine mapping of the infarcted area with precise, local …

Synthesis, characterization and therapeutic efficacy of a biodegradable, thermoresponsive hydrogel designed for application in chronic infarcted myocardium

KL Fujimoto, Z Ma, DM Nelson, R Hashizume, J Guan… - Biomaterials, 2009 - Elsevier
Injection of a bulking material into the ventricular wall has been proposed as a therapy to
prevent progressive adverse remodeling due to high wall stresses that develop after …

Injectable, rapid gelling and highly flexible hydrogel composites as growth factor and cell carriers

F Wang, Z Li, M Khan, K Tamama, P Kuppusamy… - Acta biomaterialia, 2010 - Elsevier
A family of injectable, rapid gelling and highly flexible hydrogel composites capable of
releasing insulin-like growth factor (IGF-1) and delivering mesenchymal stromal cell (MSC) …

Injectable pH- and Temperature-Responsive Poly(N-isopropylacrylamide-co-propylacrylic acid) Copolymers for Delivery of Angiogenic Growth Factors

JC Garbern, AS Hoffman, PS Stayton - Biomacromolecules, 2010 - ACS Publications
A new sharply pH-and temperature-responsive hydrogel system was designed for delivering
drugs to regions of local acidosis, as found in wound healing, tumor sites, or sites of …

Injectable, Degradable Thermoresponsive Poly(N-isopropylacrylamide) Hydrogels

M Patenaude, T Hoare - ACS Macro Letters, 2012 - ACS Publications
Degradable, covalently in situ gelling analogues of thermoresponsive poly (N-
isopropylacrylamide)(PNIPAM) hydrogels have been designed by mixing aldehyde and …

In-situ injectable physically and chemically gelling NIPAAm-based copolymer system for embolization

BH Lee, B West, R McLemore, C Pauken… - …, 2006 - ACS Publications
The goal of this work is to make an injectable physically and chemically cross-linking
NIPAAm-based copolymer system for endovascular embolization. A copolymer with N …

Degradation, cytotoxicity, and biocompatibility of NIPAAm‐based thermosensitive, injectable, and bioresorbable polymer hydrogels

Z Cui, BH Lee, C Pauken… - Journal of Biomedical …, 2011 - Wiley Online Library
A thermosensitive, injectable, and bioresorbable polymer hydrogel, poly (N‐
isopropylacrylamide‐co‐dimethyl‐γ‐butyrolactone acrylate‐co‐acrylic acid)[poly (NDBA)] …