Dopamine metabolism, alpha-synuclein pathology, and iron homeostasis have all been
implicated as potential contributors to the unique vulnerability of substantia nigra …

Dopamine was first identified as a neurotransmitter localized to the midbrain over 50 years
ago. The dopamine transporter (DAT; SLC 6A3) and the vesicular monoamine transporter 2 …

The exposure of the human population to environmental contaminants is recognized as a
significant contributing factor for the development of Parkinson's disease (PD) and other …

In the last few years, it has become clear that a wide variety of environmental contaminants
have specific effects on neuroendocrine systems in fish, amphibians, birds and mammals …

Many toxic substances have been distributed to the environment, some of which have
properties that promote accumulation and biomagnification in living organisms …

Background Early life stages are generally most sensitive to toxic effects. Our knowledge on
the action of manmade chemicals on the developing vertebrate embryo is, however, rather …

Persistent organic pollutants (POPs) are long-lived toxic organic compounds and are of
major concern for human and ecosystem health. Although the use of most POPs is banned …

Exposure to certain chemicals prenatally and in childhood can impact development and may
increase risk for attention-deficit/hyperactivity disorder (ADHD). Leveraging a larger set of …

The central nervous system is not a static, hard-wired organ. Examples of neuroplasticity,
whether at the level of the synapse, the cell, or within and between circuits, can be found …

Organohalogen compounds (OHCs) have been used and still are used extensively as
pesticides, flame retardants, hydraulic fluids, and in other industrial applications. These …