Recent advances in Alzheimer's disease: Mechanisms, clinical trials and new drug development strategies

J Zhang, Y Zhang, J Wang, Y Xia, J Zhang… - Signal transduction and …, 2024 - nature.com
Alzheimer's disease (AD) stands as the predominant form of dementia, presenting significant
and escalating global challenges. Its etiology is intricate and diverse, stemming from a …

Alzheimer's therapeutic development: shifting neurodegeneration to neuroregeneration

MK Sun, DL Alkon - Trends in Pharmacological Sciences, 2024 - cell.com
Abstract Alzheimer's disease (AD), similar to AD-related dementias, is characterized by
impaired/lost neuronal structures and functions due to a long progression of …

Microglia either promote or restrain TRAIL-mediated excitotoxicity caused by Aβ1−42 oligomers

J Zou, E McNair, S DeCastro, SP Lyons… - Journal of …, 2024 - Springer
Background Alzheimer's disease (AD) features progressive neurodegeneration and
microglial activation that results in dementia and cognitive decline. The release of soluble …

Advances in gene and cellular therapeutic approaches for Huntington's disease

X Piao, D Li, H Liu, Q Guo, Y Yu - Protein & Cell, 2024 - academic.oup.com
Huntington's disease (HD) is an inherited neurodegenerative disorder caused by the
abnormal expansion of CAG trinucleotide repeats in the Huntingtin gene (HTT) located on …

Partial microglial depletion and repopulation exert subtle but differential effects on amyloid pathology at different disease stages

LHD Le, MK O'Banion, AK Majewska - Scientific Reports, 2024 - nature.com
Abstract Colony-stimulating factor-1-receptor (CSF1R) inhibitors have been widely used to
rapidly deplete microglia from the brain, allowing the remaining microglia population to self …

The intricate interplay between microglia and adult neurogenesis in Alzheimer's disease

I Früholz, M Meyer-Luehmann - Frontiers in Cellular Neuroscience, 2024 - frontiersin.org
Microglia, the resident immune cells of the central nervous system, play a crucial role in
regulating adult neurogenesis and contribute significantly to the pathogenesis of Alzheimer's …

Long‐term reprogramming of primed microglia after moderate inhibition of CSF1R signaling

A León‐Rodríguez, JM Grondona, S Marín‐Wong… - Glia, 2025 - Wiley Online Library
In acute neuroinflammation, microglia activate transiently, and return to a resting state later
on. However, they may retain immune memory of such event, namely priming. Primed …

The compound (E)-2-(3, 4-dihydroxystyryl)-3-hydroxy-4H-pyran-4-one alleviates neuroinflammation and cognitive impairment in a mouse model of Alzheimer's …

X Liu, W Wu, X Li, C Wang, K Chai, F Yuan… - Neural Regeneration …, 2025 - journals.lww.com
Alzheimer's disease (AD) is a neurological disease that causes cognitive impairment,
abnormal behavior, and personality changes, and eventually leads to dementia and death …

Role of microglia polarization induced by glucose metabolism disorder in the cognitive impairment of mice from PM2. 5 exposure

X Zheng, F Hu, X Chen, G Yang, M Li, Y Peng… - Science of The Total …, 2024 - Elsevier
Studies have found that PM 2.5 can damage the brain, accelerate cognitive impairment, and
increase the risk of developing a variety of neurodegenerative diseases. However, the …

[HTML][HTML] Microglial and neuronal fates following inhibition of CSF-1R in synucleinopathy mouse model

M Iba, YJ Lee, L Horan-Portelance, K Chang… - Brain, Behavior, and …, 2025 - Elsevier
Synucleinopathies are age-related neurological disorders characterized by the abnormal
accumulation of α-synuclein (α-syn) in neuronal and non-neuronal cells. It has been …