Abstract Alzheimer's disease (AD), similar to AD-related dementias, is characterized by impaired/lost neuronal structures and functions due to a long progression of …
J Zou, E McNair, S DeCastro, SP Lyons… - Journal of …, 2024 - Springer
Background Alzheimer's disease (AD) features progressive neurodegeneration and microglial activation that results in dementia and cognitive decline. The release of soluble …
X Piao, D Li, H Liu, Q Guo, Y Yu - Protein & Cell, 2024 - academic.oup.com
Huntington's disease (HD) is an inherited neurodegenerative disorder caused by the abnormal expansion of CAG trinucleotide repeats in the Huntingtin gene (HTT) located on …
Abstract Colony-stimulating factor-1-receptor (CSF1R) inhibitors have been widely used to rapidly deplete microglia from the brain, allowing the remaining microglia population to self …
I Früholz, M Meyer-Luehmann - Frontiers in Cellular Neuroscience, 2024 - frontiersin.org
Microglia, the resident immune cells of the central nervous system, play a crucial role in regulating adult neurogenesis and contribute significantly to the pathogenesis of Alzheimer's …
In acute neuroinflammation, microglia activate transiently, and return to a resting state later on. However, they may retain immune memory of such event, namely priming. Primed …
X Liu, W Wu, X Li, C Wang, K Chai, F Yuan… - Neural Regeneration …, 2025 - journals.lww.com
Alzheimer's disease (AD) is a neurological disease that causes cognitive impairment, abnormal behavior, and personality changes, and eventually leads to dementia and death …
X Zheng, F Hu, X Chen, G Yang, M Li, Y Peng… - Science of The Total …, 2024 - Elsevier
Studies have found that PM 2.5 can damage the brain, accelerate cognitive impairment, and increase the risk of developing a variety of neurodegenerative diseases. However, the …
M Iba, YJ Lee, L Horan-Portelance, K Chang… - Brain, Behavior, and …, 2025 - Elsevier
Synucleinopathies are age-related neurological disorders characterized by the abnormal accumulation of α-synuclein (α-syn) in neuronal and non-neuronal cells. It has been …